Increases in calorie consumption and sedentary lifestyles are fuelling a global pandemic of
cardiometabolic diseases, including coronary artery disease, diabetes mellitus …

The physiological roles played by the tripeptide glutathione have greatly advanced over the
past decades superimposing the research on free radicals, oxidative stress and, more …

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, and scientific studies consistently report that NAFLD development can be …

It is extensively verified that continued oxidative stress and oxidative damage may lead to
chronic inflammation, which in turn can mediate most chronic diseases including cancer …

The cerebral hypoxia-ischemia can induce a wide spectrum of biologic responses that
include depolarization, excitotoxicity, oxidative stress, inflammation, and apoptosis, and …

Autophagy is a self‐degradative process that plays a pivotal role in several medical
conditions associated with infection, cancer, neurodegeneration, aging, and metabolic …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Oxidative stress including DNA damage, increased lipid and protein oxidation, are important
features of aging and neurodegeneration suggesting that endogenous antioxidant protective …

Autophagy is an important cell recycling program responsible for the clearance of damaged
or long-lived proteins and organelles. Pharmacological modulators of this pathway have …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that results from the
loss of upper and lower motor neurons. One of the key pathological hallmarks in diseased …