In patients with multiple sclerosis (MS), grey matter damage is widespread and might
underlie many of the clinical symptoms, especially cognitive impairment. This relation …

The uncinate fasciculus is a bidirectional, long-range white matter tract that connects lateral
orbitofrontal cortex and Brodmann area 10 with the anterior temporal lobes. Although …

White matter makes up about fifty percent of the human brain. Maturation of white matter
accompanies biological development and undergoes the most dramatic changes during …

Background: Cognitive impairment in MS impacts negatively on many patients at all disease
stages and in all subtypes. Full clinical cognitive assessment is expensive, requiring expert …

The greater expansion of the frontal lobes along the phylogeny scale has been interpreted
as the signature of evolutionary changes underlying higher cognitive abilities in humans …

Cognitive impairment affects a large proportion of patients with multiple sclerosis (MS) and
has a profound impact on their daily-life activities. Improving the knowledge of the …

Multiple sclerosis (MS) is a neurological disease of the central nervous system which can
lead to a range of severe physical disabilities. A large proportion of those affected will …

The fornix is a part of the limbic system and constitutes the major efferent and afferent white
matter tracts from the hippocampi. The underdevelopment of or injuries to the fornix are …

Severe cognitive impairment involving multiple cognitive domains can occur early during the
course of multiple sclerosis (MS). We investigated resting state functional connectivity …

Objective: To assess the correlation between cognitive impairment and overall vs regional
CNS damage, quantified using conventional and diffusion tensor (DT) MRI tractography in …