Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Histone deacetylases (HDACs) are part of a vast family of enzymes that have crucial roles in
numerous biological processes, largely through their repressive influence on transcription …

Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …

The past 15 years have witnessed tremendous progress in the molecular understanding of
osteoblasts, the main bone-forming cells in the vertebrate skeleton. In particular, all of the …

Histone deacetylases (HDACs) are considered to be among the most promising targets in
drug development for cancer therapy, and first-generation histone deacetylase inhibitors …

Calcification of the aortic valve is the third leading cause of heart disease in adults. The
incidence increases with age, and it is often associated with a bicuspid aortic valve present …

Endochondral ossification is the process by which the embryonic cartilaginous model of
most bones contributes to longitudinal growth and is gradually replaced by bone. During …

Protein lysine deacetylases have a pivotal role in numerous biological processes and can
be divided into the Rpd3/Hda1 and sirtuin families, each having members in diverse …

Histone deacetylase inhibitors (HDACi) comprise structurally diverse compounds that are a
group of targeted anticancer agents. The first of these new HDACi, vorinostat …

Objectives Understanding the molecular mechanisms underlying human cartilage
degeneration and regeneration is helpful for improving therapeutic strategies for treating …