Synergistic association of Aβ and tau pathology with cortical neurophysiology and cognitive decline in asymptomatic older adults
J Gallego-Rudolf, AI Wiesman, A Pichet Binette… - Nature …, 2024 - nature.com
Animal and computational models of Alzheimer's disease (AD) indicate that early amyloid-β
(Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions …
(Aβ) deposits drive neurons into a hyperactive regime, and that subsequent tau depositions …
[HTML][HTML] Long-lasting effects of very preterm birth on brain structure in adulthood: A systematic review and meta-analysis
Early life experiences, such as very preterm (VP) birth, can affect brain and cognitive
development. Several prior studies investigated brain structure in adults born VP; …
development. Several prior studies investigated brain structure in adults born VP; …
Localization patterns of speech and language errors during awake brain surgery: a systematic review
E Collée, A Vincent, E Visch-Brink, E De Witte… - Neurosurgical …, 2023 - Springer
Awake craniotomy with direct electrical stimulation (DES) is the standard treatment for
patients with eloquent area gliomas. DES detects speech and language errors, which …
patients with eloquent area gliomas. DES detects speech and language errors, which …
Neuroanatomical changes observed over the course of a human pregnancy
L Pritschet, CM Taylor, D Cossio, J Faskowitz… - Nature …, 2024 - nature.com
Pregnancy is a period of profound hormonal and physiological changes experienced by
millions of women annually, yet the neural changes unfolding in the maternal brain …
millions of women annually, yet the neural changes unfolding in the maternal brain …
Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing
Most transcriptome-wide association studies (TWASs) so far focus on European ancestry
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
and lack diversity. To overcome this limitation, we aggregated genome-wide association …
[HTML][HTML] Reliability of structural MRI measurements: The effects of scan session, head tilt, inter-scan interval, acquisition sequence, FreeSurfer version and processing …
Background Large-scale longitudinal and multi-centre studies are used to explore
neuroimaging markers of normal ageing, and neurodegenerative and mental health …
neuroimaging markers of normal ageing, and neurodegenerative and mental health …
Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data
Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …
Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders
The deviation between chronological age and age predicted using brain MRI is a putative
marker of overall brain health. Age prediction based on structural MRI data shows high …
marker of overall brain health. Age prediction based on structural MRI data shows high …
Cortical hypometabolism reflects local atrophy and tau pathology in symptomatic Alzheimer's disease
Posterior cortical hypometabolism measured with 18F-fluorodeoxyglucose (FDG)-PET is a
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
well-known marker of Alzheimer's disease-related neurodegeneration, but its associations …
Cellular correlates of cortical thinning throughout the lifespan
Cortical thinning occurs throughout the entire life and extends to late-life neurodegeneration,
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …
yet the neurobiological substrates are poorly understood. Here, we used a virtual-histology …