Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy
L Dai, M Yao, Z Fu, X Li, X Zheng, S Meng… - Nature …, 2022 - nature.com
Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …
An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers
J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …
Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy†
N Mariño‐Ocampo… - Photochemistry and …, 2023 - Wiley Online Library
Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which
is currently used to treat cancerous lesions and tumors that have been in the spotlight for its …
is currently used to treat cancerous lesions and tumors that have been in the spotlight for its …
Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease
Highlights•Statins possess pleiotropic effects independent of their lipid-lowering
activity.•Statins have have both proangiogenic and antiangiogenic properties.•Low statin …
activity.•Statins have have both proangiogenic and antiangiogenic properties.•Low statin …
Shape-dependent cellular uptake of iron oxide nanorods: mechanisms of endocytosis and implications on cell labeling and cellular delivery
The effects of nanoparticle morphology, especially size and shape, on their interactions with
cells are of great interest in understanding the fate of nanoparticles in biological systems …
cells are of great interest in understanding the fate of nanoparticles in biological systems …
In-situ vaccination using dual responsive organelle targeted nanoreactors
The poor translation of nanomedicines from bench to bedside can be attributed to (i) lack of
a delivery system with precise drug compositions with no batch-to-batch variations,(ii) off …
a delivery system with precise drug compositions with no batch-to-batch variations,(ii) off …
Bioengineered immunomodulatory organelle targeted nanozymes for photodynamic immunometabolic therapy
Intelligent nanomedicines integrated with stimuli-responsive components enable on-
demand customizable treatment options which would improve therapeutic outcome and …
demand customizable treatment options which would improve therapeutic outcome and …
Statins and angiogenesis in non-cardiovascular diseases
Statins inhibit HMG-CoA reductase by competitively inhibiting the active site of the enzyme,
thus preventing cholesterol synthesis and reducing the risk of develo** cardiovascular …
thus preventing cholesterol synthesis and reducing the risk of develo** cardiovascular …
Screening of dual chemo-photothermal cellular nanotherapies in organotypic breast cancer 3D spheroids
Living therapeutics approaches that exploit mesenchymal stem cells (MSCs) as
nanomedicine carriers are highly attractive due to MSCs native tropism toward the 3D tumor …
nanomedicine carriers are highly attractive due to MSCs native tropism toward the 3D tumor …
Chemotherapeutics used for high-risk neuroblastoma therapy improve the efficacy of anti-GD2 antibody dinutuximab beta in preclinical spheroid models
S Troschke-Meurer, M Zumpe, L Meißner, N Siebert… - Cancers, 2023 - mdpi.com
Simple Summary We investigated the effects of chemotherapeutics used for the frontline
treatment of newly diagnosed high-risk neuroblastoma patients in combination with anti …
treatment of newly diagnosed high-risk neuroblastoma patients in combination with anti …