Multifunctional metal-organic framework-based nanoreactor for starvation/oxidation improved indoleamine 2, 3-dioxygenase-blockade tumor immunotherapy

L Dai, M Yao, Z Fu, X Li, X Zheng, S Meng… - Nature …, 2022 - nature.com
Inhibited immune response and low levels of delivery restrict starvation cancer therapy
efficacy. Here, we report on the co-delivery of glucose oxidase (GOx) and indoleamine 2, 3 …

An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers

J An, S Tang, G Hong, W Chen, M Chen, J Song… - Nature …, 2022 - nature.com
The most common working mechanism of photodynamic therapy is based on high-toxicity
singlet oxygen, which is called Type II photodynamic therapy. But it is highly dependent on …

Recent Photosensitizer Developments, Delivery Strategies and Combination‐based Approaches for Photodynamic Therapy

N Mariño‐Ocampo… - Photochemistry and …, 2023 - Wiley Online Library
Photodynamic therapy of cancer (PDT) is a therapeutic technique, minimally invasive, which
is currently used to treat cancerous lesions and tumors that have been in the spotlight for its …

Pleiotropic properties of statins via angiogenesis modulation in cardiovascular disease

F Zahedipour, AE Butler, AH Eid, A Sahebkar - Drug Discovery Today, 2022 - Elsevier
Highlights•Statins possess pleiotropic effects independent of their lipid-lowering
activity.•Statins have have both proangiogenic and antiangiogenic properties.•Low statin …

Shape-dependent cellular uptake of iron oxide nanorods: mechanisms of endocytosis and implications on cell labeling and cellular delivery

AM Thamizhchelvan, H Ma, T Wu, D Nguyen… - Nanoscale, 2024 - pubs.rsc.org
The effects of nanoparticle morphology, especially size and shape, on their interactions with
cells are of great interest in understanding the fate of nanoparticles in biological systems …

In-situ vaccination using dual responsive organelle targeted nanoreactors

V Sunil, A Mozhi, W Zhan, JH Teoh, PB Ghode… - Biomaterials, 2022 - Elsevier
The poor translation of nanomedicines from bench to bedside can be attributed to (i) lack of
a delivery system with precise drug compositions with no batch-to-batch variations,(ii) off …

Bioengineered immunomodulatory organelle targeted nanozymes for photodynamic immunometabolic therapy

V Sunil, JH Teoh, BC Mohan, A Mozhi… - Journal of Controlled …, 2022 - Elsevier
Intelligent nanomedicines integrated with stimuli-responsive components enable on-
demand customizable treatment options which would improve therapeutic outcome and …

Statins and angiogenesis in non-cardiovascular diseases

F Zahedipour, AE Butler, M Rizzo, A Sahebkar - Drug Discovery Today, 2022 - Elsevier
Statins inhibit HMG-CoA reductase by competitively inhibiting the active site of the enzyme,
thus preventing cholesterol synthesis and reducing the risk of develo** cardiovascular …

Screening of dual chemo-photothermal cellular nanotherapies in organotypic breast cancer 3D spheroids

LP Ferreira, VM Gaspar, MV Monteiro, B Freitas… - Journal of Controlled …, 2021 - Elsevier
Living therapeutics approaches that exploit mesenchymal stem cells (MSCs) as
nanomedicine carriers are highly attractive due to MSCs native tropism toward the 3D tumor …

Chemotherapeutics used for high-risk neuroblastoma therapy improve the efficacy of anti-GD2 antibody dinutuximab beta in preclinical spheroid models

S Troschke-Meurer, M Zumpe, L Meißner, N Siebert… - Cancers, 2023 - mdpi.com
Simple Summary We investigated the effects of chemotherapeutics used for the frontline
treatment of newly diagnosed high-risk neuroblastoma patients in combination with anti …