JAK-STAT pathway inhibition and their implications in COVID-19 therapy

S Satarker, AA Tom, RA Shaji, A Alosious… - Postgraduate …, 2021 - Taylor & Francis
As the incidence of COVID-19 increases with time, more and more efforts are made to pave
a way out for the therapeutic strategies to deal with the disease progression. Inflammation …

Immunopathological similarities between COVID-19 and influenza: Investigating the consequences of Co-infection

H Khorramdelazad, MH Kazemi, A Najafi… - Microbial …, 2021 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has been a global public health emergency since …

An insight overview on COVID-19 mRNA vaccines: advantageous, pharmacology, mechanism of action, and prospective considerations

MS Mirtaleb, R Falak, J Heshmatnia… - International …, 2023 - Elsevier
The worldwide spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has urged scientists to present some novel vaccine platforms during this pandemic to …

[HTML][HTML] Potential therapeutic agents to COVID-19: An update review on antiviral therapy, immunotherapy, and cell therapy

MS Mirtaleb, AH Mirtaleb, H Nosrati… - Biomedicine & …, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China,
in December 2020 and coronavirus disease 19 (COVID-19) was later announced as …

Angiotensin system polymorphisms' in SARS-CoV-2 positive patients: assessment between symptomatic and asymptomatic patients: a pilot study

C Cafiero, F Rosapepe, R Palmirotta, A Re… - Pharmacogenomics …, 2021 - Taylor & Francis
Introduction The renin–angiotensin–aldosterone system (RAAS), a metabolic cascade
regulating pressure and circulating blood volume, has been considered the main system …

[HTML][HTML] A contemporary review on the important role of in silico approaches for managing different aspects of COVID-19 crisis

M Moradi, R Golmohammadi, A Najafi… - Informatics in Medicine …, 2022 - Elsevier
In the last century, the emergence of in silico tools has improved the quality of healthcare
studies by providing high quality predictions. In the case of COVID-19, these tools have …

Comparative susceptibility of SARS-CoV-2, SARS-CoV, and MERS-CoV across mammals

M Li, J Du, W Liu, Z Li, F Lv, C Hu, Y Dai… - The ISME …, 2023 - academic.oup.com
Exploring wild reservoirs of pathogenic viruses is critical for their long-term control and for
predicting future pandemic scenarios. Here, a comparative in vitro infection analysis was first …

Bioinformatics-based investigation on the genetic influence between SARS-CoV-2 infections and idiopathic pulmonary fibrosis (IPF) diseases, and drug repurposing

MA Islam, MK Kibria, MB Hossen, MS Reza… - Scientific Reports, 2023 - nature.com
Some recent studies showed that severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) infections and idiopathic pulmonary fibrosis (IPF) disease might stimulate each other …

Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality

A Budhraja, A Basu, A Gheware… - Disease Models & …, 2022 - journals.biologists.com
To elucidate the molecular mechanisms that manifest lung abnormalities during severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole …

A multiscale mechanistic model of human dendritic cells for in-silico investigation of immune responses and novel therapeutics discovery

SS Aghamiri, BL Puniya, R Amin, T Helikar - Frontiers in Immunology, 2023 - frontiersin.org
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) with the unique ability
to mediate inflammatory responses of the immune system. Given the critical role of DCs in …