ABSTRACT Polysorbates 20 and 80 (Tween® 20 and Tween® 80) are used in the
formulation of biotherapeutic products for both preventing surface adsorption and as …

To ensure the stability of biologicals over their entire shelf-life, non-ionic surface-active
compounds (surfactants) are added to protect biologics from denaturation and particle …

Surfactin, an acidic lipopeptide produced by various strains of Bacillus subtilis, behaves as a
very powerful biosurfactant and possesses several other interesting biological activities. This …

Advances in light-sheet and confocal microscopy now allow imaging of cleared large
biological tissue samples and enable the 3D appreciation of cell and protein localization in …

Among many other applications, polysorbates (PSs) are used as the most common
surfactants in biopharmaceutical products in particular to protect proteins against interfacial …

Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments
comprised of the microtubule-associated protein tau. In vitro, fibrillization of recombinant tau …

As shown earlier, raft-like domains resembling those thought to be present in natural cell
membranes can be formed in supported planar lipid monolayers. These liquid-ordered …

The amount of information generated by intensive studies of biological membranes over the
past years is such that a comprehensive treatise is now a major undertaking. This new …

We have developed a microfabricated analytical device on a glass chip that performs a
protein sizing assay, by integrating the required separation, staining, virtual destaining, and …

Purpose Polysorbates are commonly added to protein formulations and serve an important
function as stabilizers. This paper reviews recent literature detailing some of the issues seen …