Circulating HPV DNA in HPV-associated cancers

G Lin, J Li - Clinica Chimica Acta, 2023 - Elsevier
Human papillomavirus (HPV) infections are the primary cause of almost all cervical cancers,
anal cancers, and a variable proportion of other anogenital tumors, as well as head and …

Causes and consequences of HPV integration in head and neck squamous cell carcinomas: state of the art

H Balaji, I Demers, N Wuerdemann, J Schrijnder… - Cancers, 2021 - mdpi.com
Simple Summary In human papillomavirus (HPV) associated head and neck squamous cell
carcinomas (HNSCC) s, the HPV genome is commonly found integrated in the human …

Mouse papillomavirus type 1 (MmuPV1) DNA is frequently integrated in benign tumors by microhomology-mediated end-joining

L Yu, V Majerciak, XY Xue, A Uberoi, A Lobanov… - PLoS …, 2021 - journals.plos.org
MmuPV1 is a useful model for studying papillomavirus-induced tumorigenesis. We used
RNA-seq to look for chimeric RNAs that map to both MmuPV1 and host genomes. In tumor …

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

L Yu, V Majerciak, A Lobanov, S Mirza, V Band, H Liu… - Mbio, 2024 - Am Soc Microbiol
The integration of HPV DNA into human chromosomes plays a pivotal role in the onset of
papillomavirus-related cancers. HPV DNA integration often occurs by linearizing the viral …

Human papillomavirus detection by whole-genome next-generation sequencing: importance of validation and quality assurance procedures

LS Arroyo Mühr, D Guerendiain, K Cuschieri… - Viruses, 2021 - mdpi.com
Next-generation sequencing (NGS) yields powerful opportunities for studying human
papillomavirus (HPV) genomics for applications in epidemiology, public health, and clinical …

[HTML][HTML] Oral and oropharyngeal cancers and possible risk factors across Gulf Cooperation Council countries: a systematic review

WS Alqahtani, NA Almufareh, HA Al-Johani… - World Journal of …, 2020 - ncbi.nlm.nih.gov
Background In recent years, there is an emerging increase in the prevalence of oral and
oropharyngeal cancers (O-OPCs) across the Arabian Gulf Cooperation Council (GCC) …

Tumorigenic activation around HPV integrated sites in head and neck squamous cell carcinoma

M Mima, A Okabe, T Hoshii… - … Journal of Cancer, 2023 - Wiley Online Library
Human papillomavirus (HPV) is causally involved in the development of head and neck
squamous cell carcinoma (HNSCC). The integration of HPV drives tumorigenesis through …

Intratumor heterogeneity of HPV integration in HPV-associated head and neck cancer

N Sasa, T Kishikawa, M Mori, R Ito, Y Mizoro… - Nature …, 2025 - nature.com
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head
and neck squamous cell carcinoma (HPV+ HNSCC). Whole-genome sequencing of 51 …

[HTML][HTML] HPV16 and HPV18 type-specific APOBEC3 and integration profiles in different diagnostic categories of cervical samples

S Lagström, AH Løvestad, SU Umu, OH Ambur… - Tumour Virus …, 2021 - Elsevier
Abstract Human papillomavirus (HPV) 16 and 18 are the most predominant types in cervical
cancer. Only a small fraction of HPV infections progress to cancer, indicating that additional …

Viral oncogenes, viruses, and cancer: a third-generation sequencing perspective on viral integration into the human genome

R Ye, A Wang, B Bu, P Luo, W Deng, X Zhang… - Frontiers in …, 2023 - frontiersin.org
The link between viruses and cancer has intrigued scientists for decades. Certain viruses
have been shown to be vital in the development of various cancers by integrating viral DNA …