The actin cortex is a thin layer of actin, myosin and actin-binding proteins that underlies the
membrane of most animal cells. It is highly dynamic and can undergo remodelling on …

The actomyosin cytoskeleton is responsible for most force-driven processes in cells and
tissues. How it assembles into the necessary structures at the right time and place is an …

Migration of endothelial and many other cells requires spatiotemporal regulation of
protrusive and contractile cytoskeletal rearrangements that drive local cell shape changes …

An increasing number of studies have shown that circular RNAs (circRNAs) play important
roles in malignant tumor initiation and progression; however, many circRNAs are yet …

Membrane blebbing accompanies various cellular processes, including cytokinesis,
apoptosis, and cell migration, especially invasive migration of cancer cells. Blebs are …

The plasma membrane protects the eukaryotic cell from its surroundings and is essential for
cell viability; thus, it is crucial that membrane disruptions are repaired quickly to prevent …

Despite the well-established role of actin polymerization as a driving mechanism for cell
protrusion, upregulated actin polymerization alone does not initiate protrusions. Using a …

The formation of specific cellular protrusions, plasma membrane blebs, underlies the
amoeboid mode of cell motility, which is characteristic for free-living amoebae and …

During development of metastasis, tumor cells migrate through different tissues and
encounter different extracellular matrices. An ability of cells to adapt mechanisms of their …

The ability to dynamically assemble contractile networks is required throughout cell
physiology, yet direct biophysical mechanisms regulating non-muscle myosin 2 filament …