Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

Synovial tissue macrophages (STMs) were principally recognized as having a pro-
inflammatory role in rheumatoid arthritis (RA), serving as the main producers of pathogenic …

Immune-regulatory mechanisms of drug-free remission in rheumatoid arthritis (RA) are
unknown. We hypothesized that synovial tissue macrophages (STM), which persist in …

Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …

Infiltration of memory CD4+ T cells in synovial joints of Rheumatoid Arthritis (RA) patients
has been reported since decades. Moreover, several genome wide association studies …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

The synovial tissue is an immunologically challenging environment where, under
homeostatic conditions, highly specialized subsets of immune-regulatory macrophages and …

Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The
influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that …

Lipid mediators are crucial for the pathogenesis of rheumatoid arthritis (RA); however, global
analyses have not been undertaken to systematically define the lipidome underlying the …

Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. A third of
psoriatic patients develop PsA via unknown mechanisms. No reliable diagnostic markers …