Immunoglobulin A (IgA) is the most abundant immunoglobulin synthesized in the human
body. It has the highest concentration in the mucosa and is second only to IgG in serum. IgA …

As central effectors of the adaptive immune response, immunoglobulins, or antibodies,
provide essential protection from pathogens through their ability to recognize foreign …

Hospitalized COVID-19 patients often present with a large spectrum of clinical symptoms.
There is a critical need to better understand the immune responses to SARS-CoV-2 that lead …

Recent advances in the development of therapeutic antibodies (Abs) have greatly improved
the treatment of otherwise drug-resistant cancers and autoimmune diseases. Antibody …

Immunoglobulin A (IgA) is the most abundantly produced antibody in humans. IgA is a
unique class of immunoglobulin due to its multiple molecular forms, and a defining …

Human IgA is comprised of two subclasses, IgA1 and IgA2. Monomeric IgA (mIgA),
polymeric IgA (pIgA), and secretory IgA (SIgA) are the main molecular forms of IgA. The …

Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the
precise role of B cells in the pathogenesis is not fully understood. This is exemplified by the …

Members of the Fc receptor-like (FCRL) family modulate B and T cell responses, yet their
functional roles remain enigmatic. Nevertheless, FCRL3 promoter polymorphism that alters …

In patients with primary Sjögren's syndrome (pSS), inflamed salivary gland (SG) tissue may
contain lymphoepithelial lesions (LELs). LELs are histopathological phenomena whereby B …

Most B cells in the human body are present in tissues where they support immune
responses to pathogens, vaccines, autoantigens, and tumours. Despite their clear …