Significant advances in biomaterials, stem cell biology, and microscale technologies have
enabled the fabrication of biologically relevant tissues and organs. Such tissues and organs …

The liver is the largest internal organ of the body with complex microarchitecture and
function that plays critical roles in drug metabolism. Hepatotoxicity and drug-induced liver …

Skeletal muscle tissue engineering (SMTE) aims to repair or regenerate defective skeletal
muscle tissue lost by traumatic injury, tumor ablation, or muscular disease. However, two …

In pharmaceutical research, an adequate cell-based assay scheme to efficiently screen and
to validate potential drug candidates in the initial stage of drug discovery is crucial. In order …

In vitro models that capture the complexity of in vivo tissue and organ behaviors in a
scalable and easy-to-use format are desirable for drug discovery. To address this, we have …

The integration of mass transport control by means of membrane functionality into
microfluidic devices has shown substantial growth over the last 10 years. Many different …

We have developed a microfluidic 3D hepatocyte chip (3D HepaTox Chip) for in vitro drug
toxicity testing to predict in vivo drug hepatotoxicity. The 3D HepaTox Chip is based on …

Nanotechnology, science, and engineering spearhead the 21st century revolution that is
leading to fundamental breakthroughs in the way materials, devices, and systems are …

We have developed a three-dimensional (3D) liver-on-a-chip to investigate the interaction of
hepatocytes and hepatic stellate cells (HSCs) in which primary 3D hepatocyte spheroids …

In contrast to cell cultures, particularly to cell lines, tissues or organs removed from the body
cannot be maintained for long in any culture conditions. Although it is apparent that in vivo …