Antiviral approaches against influenza virus
Preventing and controlling influenza virus infection remains a global public health
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
challenge, as it causes seasonal epidemics to unexpected pandemics. These infections are …
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Watching proteins wiggle: map** structures with two-dimensional infrared spectroscopy
Proteins exhibit structural fluctuations over decades of time scales. From the picosecond
side chain motions to aggregates that form over the course of minutes, characterizing protein …
side chain motions to aggregates that form over the course of minutes, characterizing protein …
Structural basis for the function and inhibition of an influenza virus proton channel
AL Stouffer, R Acharya, D Salom, AS Levine… - Nature, 2008 - nature.com
The M2 protein from influenza A virus is a pH-activated proton channel that mediates
acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the …
acidification of the interior of viral particles entrapped in endosomes. M2 is the target of the …
Molecular dynamics, monte carlo simulations, and langevin dynamics: a computational review
Macromolecular structures, such as neuraminidases, hemagglutinins, and monoclonal
antibodies, are not rigid entities. Rather, they are characterised by their flexibility, which is …
antibodies, are not rigid entities. Rather, they are characterised by their flexibility, which is …
Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
amantadine and rimantadine, whose use has been discontinued due to widespread drug …
Water in protein hydration and ligand recognition
M Maurer, C Oostenbrink - Journal of Molecular Recognition, 2019 - Wiley Online Library
This review describes selected basics of water in biomolecular recognition. We focus on a
qualitative understanding of the most important physical aspects, how these change in …
qualitative understanding of the most important physical aspects, how these change in …
Inhibitors of the M2 proton channel engage and disrupt transmembrane networks of hydrogen-bonded waters
Water-mediated interactions play key roles in drug binding. In protein sites with sparse polar
functionality, a small-molecule approach is often viewed as insufficient to achieve high …
functionality, a small-molecule approach is often viewed as insufficient to achieve high …
Antiviral strategies against influenza virus: towards new therapeutic approaches
A Loregian, B Mercorelli, G Nannetti… - Cellular and molecular …, 2014 - Springer
Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …
millions of people worldwide and characterized by high morbidity and significant mortality …
Viroporins: structure, function and potential as antiviral targets
C Scott, S Griffin - Journal of General Virology, 2015 - microbiologyresearch.org
The channel-forming activity of a family of small, hydrophobic integral membrane proteins
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …
termed 'viroporins' is essential to the life cycles of an increasingly diverse range of RNA and …