Pharmacological and non-pharmacological approaches for the management of neuropathic pain in multiple sclerosis

AD Shkodina, M Bardhan, H Chopra, OE Anyagwa… - CNS drugs, 2024 - Springer
Multiple sclerosis is a chronic inflammatory disease that affects the central nervous system
and can cause various types of pain including ongoing extremity pain, Lhermitte's …

The disruptive relationship among circadian rhythms, pain, and opioids

JR Bumgarner, EW McCray, RJ Nelson - Frontiers in Neuroscience, 2023 - frontiersin.org
Pain behavior and the systems that mediate opioid analgesia and opioid reward processing
display circadian rhythms. Moreover, the pain system and opioid processing systems …

Circadian pain patterns in human pain conditions–A systematic review

NN Knezevic, A Nader, I Pirvulescu, A Pynadath… - Pain …, 2023 - Wiley Online Library
Background Chronobiology is the science of how physiological processes in the body follow
a pattern of time. Pain has been shown to follow a circadian rhythm, with different types of …

DNA methylation patterns of circadian and ultradian genes are altered in the peripheral blood of patients with hidradenitis suppurativa

U Radhakrishna, U Ratnamala, DD Jhala… - Frontiers in …, 2024 - frontiersin.org
Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that
affects hair follicles in areas with apocrine sweat glands, such as the underarms, groin, and …

The challenge of ecological validity in temporomandibular disorders research

JC Nickel, YM Gonzalez, LM Gallo… - Journal of Oral …, 2024 - Wiley Online Library
Objective To review the ecological validity of outcomes from current research involving
temporomandibular disorders (TMDs), with an emphasis on chronic myofascial pain and the …

Circadian rhythm and pain: A review of current research and future implications

CJ Mun, HJ Burgess, DD Sears… - Current Sleep Medicine …, 2022 - Springer
Abstract Purpose of Review The goal is to examine the link between circadian rhythms and
pain, which may shed further light on improving pain management strategies and preventing …

Sleep phase and pre-sleep arousal predicted co-developmental trajectories of pain and insomnia within adolescence

T Arnison, MGS Schrooten, S Bauducco… - Scientific Reports, 2022 - nature.com
The onset of both chronic pain and insomnia is high during adolescence. Although a
bidirectional relationship between pain and insomnia has support, how pain and sleep co …

Suppression of neuropathic pain in the circadian clock–deficient Per2m/m mice involves up-regulation of endocannabinoid system

W Yamakawa, S Yasukochi, Y Tsurudome… - PNAS …, 2024 - academic.oup.com
Neuropathic pain often results from injuries and diseases that affect the somatosensory
system. Disruption of the circadian clock has been implicated in the exacerbation of the …

Persistent idiopathic dentoalveolar pain: Is it a central pain disorder?

GM Heir, S Ananthan, M Kalladka… - Dental …, 2023 - dental.theclinics.com
Defined by the International Classification of Orofacial Pain (ICOP) 6.3, persistent idiopathic
dentoalveolar pain (PIDP) is a persistent unilateral intraoral dentoalveolar pain, rarely …

BioClocks UK: driving robust cycles of discovery to impact

H Rees, NM Rzechorzek… - Philosophical …, 2025 - royalsocietypublishing.org
Chronobiology is a multidisciplinary field that extends across the tree of life, transcends all
scales of biological organization, and has huge translational potential. For the UK to harness …