The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Transcription factors (TFs) orchestrate the gene expression programs that define each cell's
identity. The canonical TF accomplishes this with two domains, one that binds specific DNA …

In eukaryotes, genomic DNA is extruded into loops by cohesin. By restraining this process,
the DNA-binding protein CCCTC-binding factor (CTCF) generates topologically associating …

It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …

Nuclear processes such as DNA replication, transcription, and RNA processing each
depend on the concerted action of many different protein and RNA molecules. How …

CCCTC‐binding factor (CTCF) is an eleven zinc finger (ZF), multivalent transcriptional
regulator, that recognizes numerous motifs thanks to the deployment of distinct combinations …

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …

Mammalian genomes are folded into topologically associating domains (TADs), consisting
of chromatin loops anchored by CTCF and cohesin. Some loops are cell-type specific. Here …

Nuclear factors rapidly scan the genome for their targets, but the role of nuclear organization
in such search is uncharted. Here we analyzed how multiple factors explore chromatin …