Screening and prevention of ovarian cancer

M Sideris, U Menon… - Medical Journal of …, 2024 - Wiley Online Library
Ovarian cancer remains the most lethal gynaecological malignancy with 314 000 cases and
207 000 deaths annually worldwide. Ovarian cancer cases and deaths are predicted to …

Assessing the risk of cervical neoplasia in the post‐HPV vaccination era

M Lehtinen, VN Pimenoff, B Nedjai… - … journal of cancer, 2023 - Wiley Online Library
This review is based on the recent EUROGIN scientific session:“Assessing risk of cervical
cancer in the post‐vaccination era,” which addressed the demands of cervical intraepithelial …

Cigarette smoking and e-cigarette use induce shared DNA methylation changes linked to carcinogenesis

C Herzog, A Jones, I Evans, JR Raut, M Zikan… - Cancer …, 2024 - aacrjournals.org
Tobacco use is a major modifiable risk factor for adverse health outcomes, including cancer,
and elicits profound epigenetic changes thought to be associated with long-term cancer risk …

Exploring cross-tissue DNA methylation patterns: blood–brain CpGs as potential neurodegenerative disease biomarkers

V Mendonça, SC Soares-Lima… - Communications …, 2024 - nature.com
The difficulty of obtaining samples from certain human tissues has led to efforts to find
accessible sources to analyze molecular markers derived from DNA. In this study, we look …

Endometrial cancer detection by DNA methylation analysis in cervical Papanicolaou brush samples

S Wang, C Du, M Li, B Wen, Q Shen… - … in Cancer Research …, 2024 - journals.sagepub.com
Background: Endometrial cancer (EC) is the leading gynecological cancer worldwide, yet
current EC screening approaches are not satisfying. The purpose of this retrospective study …

Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development

O Nikolaienko, HP Eikesdal, E Ognedal, B Gilje… - Genome Medicine, 2023 - Springer
Background Normal cell BRCA1 epimutations have been associated with increased risk of
triple-negative breast cancer (TNBC). However, the fraction of TNBCs that may have BRCA1 …

TP53 somatic evolution in cervical liquid-based cytology and blood from individuals with and without ovarian cancer and BRCA1 or BRCA2 germline mutations

TS Ghezelayagh, BF Kohrn, J Fredrickson… - Oncogene, 2024 - nature.com
Somatic TP53 mutations are prevalent in normal tissue but little is known about their
association with cancer risk. Cervical liquid-based cytology (LBC), commonly known as Pap …

High-grade serous ovarian cancer—A risk factor puzzle and screening fugitive

J Wilczyński, E Paradowska, M Wilczyński - Biomedicines, 2024 - mdpi.com
High-grade serous ovarian cancer (HGSOC) is the most lethal tumor of the female genital
tract. Despite extensive studies and the identification of some precursor lesions like serous …

[HTML][HTML] British Gynaecological Cancer Society (BGCS) ovarian, tubal and primary peritoneal cancer guidelines: Recommendations for practice update 2024

E Moss, A Taylor, A Andreou, C Ang, R Arora… - European Journal of …, 2024 - Elsevier
Recommendations are graded as per the Royal College of Obstetricians and
Gynaecologists document, Clinical Governance Advice No. 1: Guidance for the …

The WID‐EC test for the detection and risk prediction of endometrial cancer

JE Barrett, A Jones, I Evans, C Herzog… - … Journal of Cancer, 2023 - Wiley Online Library
The incidence of endometrial cancer is rising. Measures to identify women at risk and to
detect endometrial cancer earlier are required to reduce the morbidity triggered by the …