Common polymorphisms in DNA repair genes may alter protein function and an individual's
capacity to repair damaged DNA; deficits in repair capacity may lead to genetic instability …

In the past, hereditary ovarian carcinoma was attributed almost entirely to mutations in
BRCA1 and BRCA2, with a much smaller contribution from mutations in DNA mismatch …

Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …

Background: Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy,
responsible for 13 000 deaths per year in the United States. Risk prediction based on …

Breast cancer is the most common cancer among women. Common variants at 27 loci have
been identified as associated with susceptibility to breast cancer, and these account for∼ …

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor
genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited …

We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …

Microarrays can measure the expression of thousands of genes to identify changes in
expression between different biological states. Methods are needed to determine the …

The Ewing sarcoma family of tumors (EFT) is a group of highly malignant small round blue
cell tumors occurring in children and young adults. We report here the largest genomic …

Fanconi anemia (FA) is a rare autosomal recessive cancer susceptibility disorder
characterized by cellular hypersensitivity to mitomycin C (MMC). Six FA genes have been …