The axon initial segment: an updated viewpoint
C Leterrier - Journal of Neuroscience, 2018 - Soc Neuroscience
At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …
AIS generates and shapes the action potential before it is propagated along the axon …
Axon physiology
D Debanne, E Campanac, A Bialowas… - Physiological …, 2011 - journals.physiology.org
Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
occurs once an action potential is generated. Axon dysfunction occupies a central position in …
Signal processing in the axon initial segment
MHP Kole, GJ Stuart - Neuron, 2012 - cell.com
The axon initial segment (AIS) is a specialized membrane region in the axon of neurons
where action potentials are initiated. Crucial to the function of the AIS is the presence of …
where action potentials are initiated. Crucial to the function of the AIS is the presence of …
Neural KCNQ (Kv7) channels
DA Brown, GM Passmore - British journal of pharmacology, 2009 - Wiley Online Library
KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …
Alterations of GABAergic signaling in autism spectrum disorders
R Pizzarelli, E Cherubini - Neural plasticity, 2011 - Wiley Online Library
Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological
conditions, mainly of genetic origin, characterized by stereotyped behavior, marked …
conditions, mainly of genetic origin, characterized by stereotyped behavior, marked …
Modulation of Kv7 channels and excitability in the brain
DL Greene, N Hoshi - Cellular and Molecular Life Sciences, 2017 - Springer
Neuronal Kv7 channels underlie a voltage-gated non-inactivating potassium current known
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …
as the M-current. Due to its particular characteristics, Kv7 channels show pronounced …
The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– …
Bradykinin (BK) is an inflammatory mediator and one of the most potent endogenous pain-
inducing substances. When released at sites of tissue damage or inflammation, or applied …
inducing substances. When released at sites of tissue damage or inflammation, or applied …
Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7. 2 and Kv7. 3 potassium channel subunits
Mutations in Kv7. 2 (KCNQ2) and Kv7. 3 (KCNQ3) genes, encoding for voltage-gated K+
channel subunits underlying the neuronal M-current, have been associated with a wide …
channel subunits underlying the neuronal M-current, have been associated with a wide …
The physiology of the axon initial segment
KJ Bender, LO Trussell - Annual review of neuroscience, 2012 - annualreviews.org
The action potential generally begins in the axon initial segment (AIS), a principle confirmed
by 60 years of research; however, the most recent advances have shown that a very rich …
by 60 years of research; however, the most recent advances have shown that a very rich …
Genotype–phenotype correlations in neonatal epilepsies caused by mutations in the voltage sensor of Kv7.2 potassium channel subunits
Mutations in the KV7. 2 gene encoding for voltage-dependent K+ channel subunits cause
neonatal epilepsies with wide phenotypic heterogeneity. Two mutations affecting the same …
neonatal epilepsies with wide phenotypic heterogeneity. Two mutations affecting the same …