Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

Flecainide suppresses cardiac tachyarrhythmias including paroxysmal atrial fibrillation,
supraventricular tachycardia and arrhythmic long QT syndromes (LQTS), as well as the …

Mutations involving cardiac ion channels result in abnormal action potential formation or
propagation, leading to cardiac arrhythmias. Despite the large impact on society of sudden …

The recently described exchange protein directly activated by cAMP (Epac) has been
implicated in distinct protein kinase A-independent cellular signalling pathways. We …

Aims Clinical observations in patients with long QT syndrome carrying sodium channel
mutations (LQT3) suggest that bradycardia caused by parasympathetic stimulation may …

BACKGROUND: Patients with long QT syndrome (LQTS) are at increased risk not only for
ventricular arrhythmias but also for atrial pathology including atrial fibrillation (AF). Some …

Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common
cause of mortality and a significant public health burden. Insights into the …

An aberrant late sodium current (I Na, Late) caused by a mutation in the cardiac sodium
channel (Nav1. 5) has emerged as a contributor to electrical remodeling that causes …

Mutations of SCN5A gene, which encodes the α-subunit of the voltage-gated Na+ channel
NaV1. 5, underlie hereditary cardiac arrhythmic syndromes such as the type 3 long QT …

Acute RyR2 activation by exchange protein directly activated by cAMP (Epac) reversibly
perturbs myocyte Ca2+ homeostasis, slows myocardial action potential conduction, and …