Ca2+-ATPases (pumps) are key actors in the regulation of Ca2+ in eukaryotic cells and are
thus essential to the correct functioning of the cell machinery. They have high affinity for …

The sarcoendoplasmic reticulum (SR) calcium transport ATPase (SERCA) is a pump that
transports calcium ions from the cytoplasm into the SR. It is present in both animal and plant …

Overlap** complementary DNA clones were isolated from epithelial cell libraries with a
genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is …

Recent studies suggest that the fly uses the inositol lipid signaling system for visual
excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this …

How is the heartbeat generated? What controls the strength of contraction of heart muscle?
What are the links between cardiac structure and function? How does our understanding of …

Menkes disease is an X–linked disorder of copper transport characterized by progressive
neurological degeneration and death in early childhood. We have isolated a candidate gene …

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic
biochemistry, organic reaction mechanisms, and chemical thermody namics are well …

Darier disease (DD) is an autosomal-dominant skin disorder characterized by loss of
adhesion between epidermal cells (acantholysis) and abnormal keratinization. Recently we …

Bacteria continuously adapt to changes in their environment. Responses are largely
controlled by signal transduction systems that contain two central enzymatic components, a …

abstract Mammalian skeletal muscle is an extremely heterogeneous tissue, composed of a
large variety of fiber types. These fibers, however, are not fixed units but represent highly …