T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
CD8 T cell exhaustion during chronic viral infection and cancer
LM McLane, MS Abdel-Hakeem… - Annual review of …, 2019 - annualreviews.org
Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
and cancers in animal models and humans. Tex cells are characterized by progressive loss …
The TNF–TNFR family of co-signal molecules
T So, N Ishii - Co-signal Molecules in T Cell Activation: Immune …, 2019 - Springer
Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF)
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
TNF/TNFR Superfamily Members in Costimulation of T Cell Responses—Revisited
Prosurvival tumor necrosis factor receptor (TNFR) superfamily (TNFRSF) members on T
cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal …
cells, including 4-1BB, CD27, GITR, and OX40, support T cell accumulation during clonal …
Targeting the T-cell co-stimulatory CD27/CD70 pathway in cancer immunotherapy: rationale and potential
K Van De Ven, J Borst - Immunotherapy, 2015 - Taylor & Francis
In 2013, cancer immunotherapy was named 'breakthrough of the year'based on the outcome
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …
of clinical trials with blocking antibodies to the T-cell co-inhibitory receptors CTLA-4 and PD …
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2
KK McKinstry, TM Strutt, B Bautista, W Zhang… - Nature …, 2014 - nature.com
It is unclear how CD4 T-cell memory formation is regulated following pathogen challenge,
and when critical mechanisms act to determine effector T-cell fate. Here, we report that …
and when critical mechanisms act to determine effector T-cell fate. Here, we report that …
Plasma CD27, a surrogate of the intratumoral CD27–CD70 interaction, correlates with immunotherapy resistance in renal cell carcinoma
N Benhamouda, I Sam, N Epaillard, A Gey, L Phan… - Clinical Cancer …, 2022 - AACR
Purpose: CD70 is a costimulatory molecule known to activate CD27-expressing T cells.
CD27–CD70 interaction leads to the release of soluble CD27 (sCD27). Clear-cell renal cell …
CD27–CD70 interaction leads to the release of soluble CD27 (sCD27). Clear-cell renal cell …
CD27 signaling increases the frequency of regulatory T cells and promotes tumor growth
Signaling of the TNF receptor superfamily member CD27 activates costimulatory pathways
to elicit T-and B-cell responses. CD27 signaling is regulated by the expression of its ligand …
to elicit T-and B-cell responses. CD27 signaling is regulated by the expression of its ligand …
Co-stimulatory and co-inhibitory pathways in cancer immunotherapy
RE O'Neill, X Cao - Advances in cancer research, 2019 - Elsevier
Cancer remains the leading cause of death worldwide. Traditional treatments such as
surgery, radiation, and chemotherapy have had limited efficacy, especially with late stage …
surgery, radiation, and chemotherapy have had limited efficacy, especially with late stage …
TGF-β upregulates CD70 expression and induces exhaustion of effector memory T cells in B-cell non-Hodgkin's lymphoma
ZZ Yang, DM Grote, B **u, SC Ziesmer… - Leukemia, 2014 - nature.com
Transforming growth factor beta (TGF-β) has an important role in mediating T-cell
suppression in B-cell non-Hodgkin lymphoma (NHL). However, the underlying mechanism …
suppression in B-cell non-Hodgkin lymphoma (NHL). However, the underlying mechanism …