Hippo signaling is an evolutionarily conserved network that has a central role in regulating
cell proliferation and cell fate to control organ growth and regeneration. It promotes …

Simple Summary The Hippo pathway is crucial for regulating cell growth, organ size, and
tissue regeneration. When this pathway goes awry, it can lead to uncontrolled cell growth …

Glucose consumption is generally increased in tumor cells to support tumor growth.
Interestingly, we report that glycogen accumulation is a key initiating oncogenic event during …

The Hippo signaling pathway controls organ size and tumorigenesis through a kinase
cascade that inactivates Yes‐associated protein (YAP). Here, we show that YAP plays a …

Activation of YAP, a Hippo pathway effector, is an important resistance mechanism to BRAF
inhibitor (BRAFi) in melanoma. Emerging evidence also suggests that YAP is involved in …

Purpose: Esophageal cancer is an aggressive malignancy and often resistant to therapy.
Overexpression of EGFR has been associated with poor prognosis of patients with …

Background & Aims Pancreatitis is the most important risk factor for pancreatic ductal
adenocarcinoma (PDAC). Pancreatitis predisposes to PDAC because it induces a process …

Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious
treatment modalities. Elucidation of signaling mechanisms that will lead to the identification …

The Hippo pathway is an evolutionary conserved signaling network that regulates essential
processes such as organ size, cell proliferation, migration, stemness and apoptosis …

Mechanical stress can influence cell proliferation in vitro, but whether it makes a significant
contribution to growth control in vivo, and how it is modulated and experienced by cells …