Unique, functional, homodimeric heavy chain–only antibodies, devoid of light chains, are
circulating in the blood of Camelidae. These antibodies recognize their cognate antigen via …

A nanobody (Nb) is a registered trademark of Ablynx, referring to the single antigen‐binding
domain of heavy chain‐only antibodies (HCAbs) that are circulating in Camelidae. Nbs are …

Extracellular vesicles (EVs), such as exosomes, can mediate long-distance communication
between cells by delivering biomolecular cargo. It is speculated that EVs undergo back …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

Specialized epitope tags are widely used for detecting, manipulating or purifying proteins,
but often their versatility is limited. Here, we introduce the ALFA-tag, a rationally designed …

Prion disease is caused by misfolding of the prion protein (PrP) into pathogenic self-
propagating conformations, leading to rapid-onset dementia and death. However …

Certain obligate parasites induce complex and substantial phenotypic changes in their hosts
in ways that favor their transmission to other trophic levels. However, the mechanisms …

The multimodal lateral flow immunoassay (LFIA) has provided accurate and reliable results
for fast and immediate detection. Nonetheless, multimodal LFIA remains challenging to …

Highlights•Nanobodies (Nbs) are camelid-derived single-domain antibodies.•Nbs have
powerful binding and inhibitory capacity with great therapeutic potential.•Nbs are used in …

Sera of camelids contain both conventional heterotetrameric antibodies and unique
functional heavy (H)-chain antibodies (HCAbs). The H chain of these homodimeric …