Oxygen (O 2) toxicity remains a concern, particularly to the lung. This is mainly related to
excessive production of reactive oxygen species (ROS). Supplemental O 2, ie inspiratory O …

This scientific statement presents a conceptual framework for the pathophysiology of post–
cardiac arrest brain injury, explores reasons for previous failure to translate preclinical data …

Background Patients with acute hypoxemic respiratory failure in the intensive care unit (ICU)
are treated with supplemental oxygen, but the benefits and harms of different oxygenation …

Background There is insufficient research into the use of mechanical ventilation with
increased inspiratory oxygen concentration (FiO 2) and fluid resuscitation with hypertonic …

Oxygen is toxic across all three domains of life. Yet, the underlying molecular mechanisms
remain largely unknown. Here, we systematically investigate the major cellular pathways …

Rationale: Supplemental oxygen is widely administered to ICU patients, but appropriate
oxygenation targets remain unclear. Objectives: This study aimed to determine whether a …

Background Providing supplemental oxygen is fundamental in the management of
mechanically ventilated patients. Increasing amounts of data show worse clinical outcomes …

Purpose The effect of high arterial oxygen levels and supplemental oxygen administration
on outcomes in traumatic brain injury (TBI) is debated, and data from large cohorts of TBI …

Background Studies investigating the role of hyperoxia in critically ill patients have reported
conflicting results. We did this analysis to reveal the effect of hyperoxia in the patients …

Background Although low oxygen saturations are generally regarded as deleterious, recent
studies in ICU patients have shown that a liberal oxygen strategy increases mortality …