Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …

Skin wounds can be classified into two categories, namely acute and chronic wounds. While
acute wounds are healed by the normal wound healing process, chronic wounds are not …

Injectable hydrogels with the capability to cast a hypoxic microenvironment is of great
potentialities to develop novel therapies for tissue regeneration. However, the relative …

Hypoxia is a unique characteristic of the solid tumor microenvironment. Hypoxia contributes
to multi-drug resistance, metastasis and cancer relapse through numerous molecular …

Stereocomplexation, or specific interactions among complementary stereoregular
macromolecules, is burgeoning as an increasingly impactful design tool, exerting exquisite …

Hypoxia is characterized as insufficient oxygen delivery to tissues and cells in the body and
is prevalent in many human physiology processes and diseases. Thus, it is an attractive …

Organoids recapitulate many aspects of the complex three-dimensional (3D) organization
found within native tissues and even display tissue and organ-level functionality. Traditional …

The heterogeneous tumor microenvironment (TME) is highly complex and not entirely
understood. These complex configurations lead to the generation of oxygen-deprived …

The establishment of tumor microenvironment using biomimetic in vitro models that
recapitulate key tumor hallmarks including the tumor supporting extracellular matrix (ECM) is …