[HTML][HTML] Brain–gut–microbiota axis in depression: A historical overview and future directions

L Chang, Y Wei, K Hashimoto - Brain Research Bulletin, 2022 - Elsevier
Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

The role of inflammation in depression and fatigue

CH Lee, F Giuliani - Frontiers in immunology, 2019 - frontiersin.org
Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Neuroinflammation in bipolar depression

F Benedetti, V Aggio, ML Pratesi, G Greco… - Frontiers in …, 2020 - frontiersin.org
Bipolar disorder (BD) is a leading cause of worldwide disability among mood disorders.
Pathological mechanisms are still vastly unclear, and current treatments with conventional …

Factors related to mental health of inpatients with COVID-19 in Wuhan, China

Y Hu, Y Chen, Y Zheng, C You, J Tan, L Hu… - Brain, behavior, and …, 2020 - Elsevier
Objective To evaluate the mental health status of hospitalized patients with coronavirus
disease 2019 (COVID-19) and to explore the related factors. Method This was a cross …

Interleukin-6 as potential mediator of long-term neuropsychiatric symptoms of COVID-19

N Kappelmann, R Dantzer, GM Khandaker - Psychoneuroendocrinology, 2021 - Elsevier
The majority of COVID-19 survivors experience long-term neuropsychiatric symptoms such
as fatigue, slee** difficulties, depression and anxiety. We propose that neuroimmune …

Peripheral blood cellular immunophenotype in depression: a systematic review and meta-analysis

ÉM Foley, JT Parkinson, RE Mitchell, L Turner… - Molecular …, 2023 - nature.com
Introduction Meta-analyses implicate immune dysfunction in depression confirming
increased levels of circulating immune proteins (eg, cytokines) in depression cases …

Beyond a neurotransmitter: The role of serotonin in inflammation and immunity

H Wu, TH Denna, JN Storkersen, VA Gerriets - Pharmacological research, 2019 - Elsevier
Abstract Serotonin (5-HT), a well-known neurotransmitter in the brain, also plays an
important role in peripheral tissues, including the immune system. There is a growing body …

The compensatory immune-regulatory reflex system (CIRS) in depression and bipolar disorder

M Maes, AF Carvalho - Molecular neurobiology, 2018 - Springer
Here, we review a novel concept namely the compensatory immune-regulatory reflex system
(CIRS) as applied to the pathophysiology of major depressive disorder (MDD) and bipolar …

Neuroinflammation, memory, and depression: new approaches to hippocampal neurogenesis

A Wu, J Zhang - Journal of Neuroinflammation, 2023 - Springer
As one of most common and severe mental disorders, major depressive disorder (MDD)
significantly increases the risks of premature death and other medical conditions for patients …

Depression's unholy trinity: dysregulated stress, immunity, and the microbiome

JS Cruz-Pereira, K Rea, YM Nolan… - Annual review of …, 2020 - annualreviews.org
Depression remains one of the most prevalent psychiatric disorders, with many patients not
responding adequately to available treatments. Chronic or early-life stress is one of the key …