Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Several large-scale genomic studies have supported an association between cases of
autism spectrum disorder and mutations in the genes SH3 and multiple ankyrin repeat …

The brain is a site of relative immune privilege. Although CD4 T cells have been reported in
the central nervous system, their presence in the healthy brain remains controversial, and …

Autism spectrum disorder (ASD) has a major impact on the development and social
integration of affected individuals and is the most heritable of psychiatric disorders. An …

Autism is a neurodevelopmental disorder characterized by deficits in communication and
social skills as well as repetitive and stereotypical behaviors. While much effort has focused …

Mutation or disruption of the SH3 and ankyrin repeat domains 3 (SHANK3) gene represents
a highly penetrant, monogenic risk factor for autism spectrum disorder, and is a cause of …

Social deficit is a core clinical feature of autism spectrum disorder (ASD) but the underlying
neural mechanisms remain largely unclear. We demonstrate that structural and functional …

The structure of neuronal circuits that subserve cognitive functions in the brain is shaped
and refined throughout development and into adulthood. Evidence from human and animal …

Sleep disturbances frequently occur in neurodevelopmental disorders such as autism, but
the developmental role of sleep is largely unexplored, and a causal relationship between …

Human neuroimaging studies suggest that aberrant neural connectivity underlies
behavioural deficits in autism spectrum disorders (ASDs), but the molecular and neural …