The development of disease-modifying therapies for osteoarthritis (DMOADs): the evidence to date
Osteoarthritis (OA) is a complex heterogeneous articular disease with multiple joint tissue
involvement of varying severity and no regulatory-agency-approved disease-modifying …
involvement of varying severity and no regulatory-agency-approved disease-modifying …
Osteoarthritis: New insight on its pathophysiology
Understanding of the basis of osteoarthritis (OA) has seen some interesting advancements
in recent years. It has been observed that cartilage degeneration is preceded by …
in recent years. It has been observed that cartilage degeneration is preceded by …
[HTML][HTML] Osteoarthritis year in review 2021: biology
Y Jiang - Osteoarthritis and cartilage, 2022 - Elsevier
This year in review on osteoarthritis biology summarizes a series of research articles
published between the 2020 and 2021 Osteoarthritis Research Society International …
published between the 2020 and 2021 Osteoarthritis Research Society International …
Electroactive biomaterials for facilitating bone defect repair under pathological conditions
Bone degeneration associated with various diseases is increasing due to rapid aging,
sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical …
sedentary lifestyles, and unhealthy diets. Living bone tissue has bioelectric properties critical …
Interplay between inflammation and pathological bone resorption: insights into recent mechanisms and pathways in related diseases for future perspectives
MA Terkawi, G Matsumae, T Shimizu… - International Journal of …, 2022 - mdpi.com
Bone is a mineralized and elastic connective tissue that provides fundamental functions in
the human body, including mechanical support to the muscles and joints, protection of vital …
the human body, including mechanical support to the muscles and joints, protection of vital …
HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways
C Bao, S Zhu, K Song, C He - Cell Communication and Signaling, 2022 - Springer
Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …
Obesity-related knee osteoarthritis—current concepts
R Shumnalieva, G Kotov, S Monov - Life, 2023 - mdpi.com
The knee is the joint most frequently involved in osteoarthritis and represents a significant
contributor to patient morbidity and impaired functional status. Major risk factors include …
contributor to patient morbidity and impaired functional status. Major risk factors include …
IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology
M Arra, G Swarnkar, Y Alippe, G Mbalaviele… - Bone Research, 2022 - nature.com
Osteoarthritis is a joint disease characterized by a poorly-defined inflammatory response
that does not encompass a massive immune cell infiltration yet contributes to cartilage …
that does not encompass a massive immune cell infiltration yet contributes to cartilage …
Latest insights in disease-modifying osteoarthritis drugs development
Osteoarthritis (OA) is a prevalent and severely debilitating disease with an unmet medical
need. In order to alleviate OA symptoms or prevent structural progression of OA, new drugs …
need. In order to alleviate OA symptoms or prevent structural progression of OA, new drugs …
[PDF][PDF] Osteoarthritis pathophysiology: therapeutic target discovery may require a multifaceted approach
TL Vincent, T Alliston, M Kapoor, RF Loeser… - Clinics in geriatric …, 2022 - Elsevier
Molecular understanding of osteoarthritis (OA) has greatly increased over the past 15 years
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …
through careful analysis of tissue samples, pre-clinical models and large-scale agnostic '∼ …