Ischemia/reperfusion injury (IRI) permeates a variety of diseases and is a ubiquitous
concern in every transplantation proceeding, from whole organs to modest grafts. Given its …

The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …

The intestinal microbiota regulates mammalian lipid absorption, metabolism, and storage.
We report that the microbiota reprograms intestinal lipid metabolism in mice by repressing …

The sirtuin family of nicotinamide adenine dinucleotide–dependent deacylases (SIRT1–7)
are thought to be responsible, in large part, for the cardiometabolic benefits of lean diets and …

Abstract The sirtuins (SIRT1–7) are a family of nicotinamide adenine dinucleotide (NAD+)-
dependent deacylases with remarkable abilities to prevent diseases and even reverse …

The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various
physiological functions, from energy metabolism to stress responses. The human Sirtuin …

NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and
maintain mitochondrial fitness through mechanisms such as the mitochondrial unfolded …

There has been an alarming increase in the prevalence of obesity in people with type 1
diabetes in recent years. Although obesity has long been recognized as a major risk factor …

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

Summary The mammalian Sir2 ortholog Sirt1 plays an important role in metabolic
regulation. However, the role of Sirt1 in the regulation of aging and longevity is still …