Rheumatoid arthritis (RA) remains a significant unmet medical need despite significant
therapeutic advances. The pathogenesis of RA is complex and includes many cell types …

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting joints and
causing progressive damage and disability. Macrophages are of critical importance in the …

The synovial joint contains synovial fluid (SF) within a cavity bounded by articular cartilage
and synovium. SF is a viscous fluid that has lubrication, metabolic, and regulatory functions …

Matricellular proteins are involved in the crosstalk between cells and their environment and
thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular …

Rheumatoid arthritis is a complex systemic disease that ultimately leads to the progressive
destruction of articular and periarticular structures. Novel data indicate that the innate …

Introduction Discrimination of rheumatoid arthritis (RA) patients from patients with other
inflammatory or degenerative joint diseases or healthy individuals purely on the basis of …

Autoimmune thyroid diseases (AITD) such as Graves' disease (GD) or Hashimoto's
thyroiditis (HT) are organ-specific diseases that involve complex interactions between …

Rheumatoid arthritis (RA) is an immune-mediated disease affecting diarthrodial joints that
remains an unmet medical need despite improved therapy. This limitation likely reflects the …

Introduction Rheumatoid arthritis (RA) is a T-cell-mediated systemic autoimmune disease,
characterized by synovium inflammation and articular destruction. Bone marrow …

RA is a heterogeneous clinical and pathobiological entity. Specific pathways within synovial
tissues are emerging as associated with diverse clinical evolution and therapeutic …