Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
Abstract Glycogen synthase kinase-3 (GSK3) may be the busiest kinase in most cells, with
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
over 100 known substrates to deal with. How does GSK3 maintain control to selectively …
The diverse roles of arrestin scaffolds in G protein–coupled receptor signaling
The visual/β-arrestins, a small family of proteins originally described for their role in the
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …
desensitization and intracellular trafficking of G protein–coupled receptors (GPCRs), have …
Teaching old receptors new tricks: biasing seven-transmembrane receptors
Abstract Seven-transmembrane receptors (7TMRs; also known as G protein-coupled
receptors) are the largest class of receptors in the human genome and are common targets …
receptors) are the largest class of receptors in the human genome and are common targets …
Dishevelled: The hub of Wnt signaling
C Gao, YG Chen - Cellular signalling, 2010 - Elsevier
Wnt signaling controls a variety of developmental and homeostatic events. As a key
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …
component of Wnt signaling, Dishevelled (Dvl/Dsh) protein relays Wnt signals from receptors …
The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors
SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …
Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions
Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is
initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein …
initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein …
[HTML][HTML] Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling
Nephronophthisis-related ciliopathies (NPHP-RC) are degenerative recessive diseases that
affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia …
affect kidney, retina, and brain. Genetic defects in NPHP gene products that localize to cilia …
Dishevelled: A masterful conductor of complex Wnt signals
The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …
G protein-coupled receptors in cancer
Despite the fact that G protein-coupled receptors (GPCRs) are the largest signal-conveying
receptor family and mediate many physiological processes, their role in tumor biology is …
receptor family and mediate many physiological processes, their role in tumor biology is …
Wnt5a regulates distinct signalling pathways by binding to Frizzled2
A Sato, H Yamamoto, H Sakane, H Koyama… - The EMBO …, 2010 - embopress.org
Wnt5a regulates multiple intracellular signalling cascades, but how Wnt5a determines the
specificity of these pathways is not well understood. This study examined whether the …
specificity of these pathways is not well understood. This study examined whether the …