Asymmetric catalysis is a major theme of research in contemporary synthetic organic
chemistry. The discovery of general strategies for highly enantioselective photochemical …

This Perspective illustrates the defining characteristics of free radical chemistry, beginning
with its rich and storied history. Studies from our laboratory are discussed along with recent …

Hydrogenation is one of the most fundamental transformations in organic synthesis, and its
industrial applications span from fine chemicals to pharmaceuticals synthesis. 1− 3 Direct …

The past decade has seen unprecedented growth in the development of new chemical
methods that proceed by mechanisms involving radical intermediates. This new attention …

Enantioselective transition metal catalysis is an area very much at the forefront of
contemporary synthetic research. The development of processes that enable the efficient …

Nitroalkanes serve as essential intermediates in the synthesis of pharmaceuticals,
agrochemicals, and functional materials. To date, nitroalkanes are mainly prepared from …

Conspectus Catalysts for asymmetric synthesis must be chiral. Metal-based asymmetric
catalysts are typically constructed by assembling chiral ligands around a central metal. In …

Stereochemical control of electronically excited states is a long-standing challenge in
photochemical synthesis, and few catalytic systems that produce high enantioselectivities in …

The Paternò–Büchi reaction is the [2+ 2] photocycloaddition of a carbonyl with an alkene to
afford an oxetane. Enantioselective catalysis of this classical photoreaction, however, has …

Asymmetric catalysis holds a prominent position among the important developments in
chemistry during the 20th century. This was acknowledged by the 2001 Nobel Prize in …