Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions?

CA Akdis - Nature Reviews Immunology, 2021 - nature.com
There has been a steep increase in allergic and autoimmune diseases, reaching epidemic
proportions and now affecting more than one billion people worldwide. These diseases are …

Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

[HTML][HTML] Pathways linking biodiversity to human health: A conceptual framework

MR Marselle, T Hartig, DTC Cox, S De Bell… - Environment …, 2021 - Elsevier
Biodiversity is a cornerstone of human health and well-being. However, while evidence of
the contributions of nature to human health is rapidly building, research into how biodiversity …

The cultural evolution of emotion

KA Lindquist, JC Jackson, J Leshin… - Nature Reviews …, 2022 - nature.com
Scholarly debates about the nature of human emotion traditionally pit biological and cultural
influences against one another. Although many existing theories acknowledge the role of …

Cellular and molecular mechanisms of allergic asthma

ZI Komlósi, W van de Veen, N Kovács, G Szűcs… - Molecular aspects of …, 2022 - Elsevier
Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

A biodiversity hypothesis

T Haahtela - Allergy, 2019 - Wiley Online Library
Biodiversity hypothesis states that contact with natural environments enriches the human
microbiome, promotes immune balance and protects from allergy and inflammatory …

A systematic review of cultural ecosystem services and human wellbeing

A Kosanic, J Petzold - Ecosystem Services, 2020 - Elsevier
Environmental degradation is increasing globally through direct anthropogenic
interventions, such as urbanisation and unsustainable land use, and human-induced …

[HTML][HTML] Exploring connections among nature, biodiversity, ecosystem services, and human health and well-being: Opportunities to enhance health and biodiversity …

PA Sandifer, AE Sutton-Grier, BP Ward - Ecosystem services, 2015 - Elsevier
We are at a key juncture in history where biodiversity loss is occurring daily and accelerating
in the face of population growth, climate change, and rampant development …

The Relationship between the Infant Gut Microbiota and Allergy. The Role of Bifidobacterium breve and Prebiotic Oligosaccharides in the Activation of Anti-Allergic …

B Cukrowska, JB Bierła, M Zakrzewska, M Klukowski… - Nutrients, 2020 - mdpi.com
The increase in allergy prevalence observed in recent decades may be a consequence of
early intestinal dysbiosis. The intestinal microbiota is formed in the first 1000 days of life …

Allergic diseases and asthma: a global public health concern and a call to action

R Pawankar - World Allergy Organization Journal, 2014 - Springer
The prevalence of allergic diseases and asthma are increasing worldwide, particularly in
low and middle income countries. Moreover, the complexity and severity of allergic …