Nucleases: diversity of structure, function and mechanism
W Yang - Quarterly reviews of biophysics, 2011 - cambridge.org
Nucleases cleave the phosphodiester bonds of nucleic acids and may be endo or exo,
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
DNase or RNase, topoisomerases, recombinases, ribozymes, or RNA splicing enzymes. In …
RNA decay machines: the exosome
A Chlebowski, M Lubas, TH Jensen… - Biochimica et Biophysica …, 2013 - Elsevier
The multisubunit RNA exosome complex is a major ribonuclease of eukaryotic cells that
participates in the processing, quality control and degradation of virtually all classes of RNA …
participates in the processing, quality control and degradation of virtually all classes of RNA …
Extensive degradation of RNA precursors by the exosome in wild-type cells
The exosome is a complex involved in the maturation of rRNA and sn-snoRNA, in the
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …
degradation of short-lived noncoding RNAs, and in the quality control of RNAs produced in …
The eukaryotic RNA exosome
K Januszyk, CD Lima - Current opinion in structural biology, 2014 - Elsevier
Highlights•Eukaryotic exosome cores and phosphorolytic exoribonucleases are structurally
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
similar.•Exosome cores include a central channel but are catalytically inert.•Central channel …
The exosome: a multipurpose RNA-decay machine
M Schmid, TH Jensen - Trends in biochemical sciences, 2008 - cell.com
The diversity of RNAs in the cell continues to amaze. In addition to the 'classic'species of
mRNA, tRNA, rRNA, snRNA and snoRNA, it is now clear that the majority of genomic …
mRNA, tRNA, rRNA, snRNA and snoRNA, it is now clear that the majority of genomic …
Structure of an Rrp6–RNA exosome complex bound to poly (A) RNA
The eukaryotic RNA exosome processes and degrades RNA by directing substrates to the
distributive or processive 3′ to 5′ exoribonuclease activities of Rrp6 or Rrp44 …
distributive or processive 3′ to 5′ exoribonuclease activities of Rrp6 or Rrp44 …
RNA degradation paths in a 12-subunit nuclear exosome complex
DL Makino, B Schuch, E Stegmann, M Baumgärtner… - Nature, 2015 - nature.com
The eukaryotic exosome is a conserved RNA-degrading complex that functions in RNA
surveillance, turnover and processing. How the same machinery can either completely …
surveillance, turnover and processing. How the same machinery can either completely …
Comparison of preribosomal RNA processing pathways in yeast, plant and human cells–focus on coordinated action of endo‐and exoribonucleases
Proper regulation of ribosome biosynthesis is mandatory for cellular adaptation, growth and
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …
proliferation. Ribosome biogenesis is the most energetically demanding cellular process …
Nuclear RNA exosome at 3.1 Å reveals substrate specificities, RNA paths, and allosteric inhibition of Rrp44/Dis3
The eukaryotic RNA exosome is an essential and conserved 3′-to-5′ exoribonuclease
complex that degrades or processes nearly every class of cellular RNA. The nuclear RNA …
complex that degrades or processes nearly every class of cellular RNA. The nuclear RNA …
The exosome‐binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase
B Schuch, M Feigenbutz, DL Makino, S Falk… - The EMBO …, 2014 - embopress.org
The exosome is a conserved multi‐subunit ribonuclease complex that functions in 3′ end
processing, turnover and surveillance of nuclear and cytoplasmic RNA s. In the yeast …
processing, turnover and surveillance of nuclear and cytoplasmic RNA s. In the yeast …