Multiple sclerosis and cognition: synaptic failure and network dysfunction

M Di Filippo, E Portaccio, A Mancini… - Nature Reviews …, 2018 - nature.com
Cognitive impairment is increasingly recognized to be a core feature of multiple sclerosis
(MS), with important implications for the everyday life of individuals with MS and for disease …

Interplay between age and neuroinflammation in multiple sclerosis: effects on motor and cognitive functions

A Musella, A Gentile, FR Rizzo, F De Vito… - Frontiers in aging …, 2018 - frontiersin.org
Aging is one of the main risk factors for the development of many neurodegenerative
diseases. Emerging evidence has acknowledged neuroinflammation as potential trigger of …

Structural plasticity of the hippocampus in neurodegenerative diseases

PDE Weerasinghe-Mudiyanselage, MJ Ang… - International journal of …, 2022 - mdpi.com
Neuroplasticity is the capacity of neural networks in the brain to alter through development
and rearrangement. It can be classified as structural and functional plasticity. The …

Multiple immune-inflammatory and oxidative and nitrosative stress pathways explain the frequent presence of depression in multiple sclerosis

G Morris, EMV Reiche, A Murru, AF Carvalho… - Molecular …, 2018 - Springer
Patients with a diagnosis of multiple sclerosis (MS) or major depressive disorder (MDD)
share a wide array of biological abnormalities which are increasingly considered to play a …

Cytokines, synaptic plasticity and network dynamics: a matter of balance

L Bellingacci, J Canonichesi, A Mancini… - Neural Regeneration …, 2023 - journals.lww.com
The modern view of the immune system as a sensitizing and modulating machinery of the
central nervous system is now well recognized. However, the specific mechanisms …

Neuroinflammation in Alzheimer's disease: pleiotropic roles for cytokines and neuronal pentraxins

A Swanson, T Wolf, A Sitzmann, AA Willette - Behavioural brain research, 2018 - Elsevier
Neuroinflammation is a potential factor speculated to underlie Alzheimer's disease (AD)
etiopathogenesis and progression. The overwhelming focus in this area of research to date …

Basic mechanisms of plasticity and learning

A Mancini, A de Iure, B Picconi - Handbook of clinical neurology, 2022 - Elsevier
The last century was characterized by a significant scientific effort aimed at unveiling the
neurobiological basis of learning and memory. Thanks to the characterization of the …

Neuro-immune cross-talk in the striatum: from basal ganglia physiology to circuit dysfunction

A Mancini, V Ghiglieri, L Parnetti, P Calabresi… - Frontiers in …, 2021 - frontiersin.org
The basal ganglia network is represented by an interconnected group of subcortical nuclei
traditionally thought to play a crucial role in motor learning and movement execution. During …

Early chronic systemic inflammation and associations with cognitive performance after moderate to severe TBI

KA Milleville, N Awan, D Disanto, RG Kumar… - Brain, Behavior, & …, 2021 - Elsevier
Background Cognitive dysfunction adversely effects multiple functional outcomes and social
roles after TBI. We hypothesize that chronic systemic inflammation exacerbates cognitive …

Sex differences in olfactory cortex neuronal loss in aging

MM Alotaibi, M De Marco, A Venneri - Frontiers in Human …, 2023 - frontiersin.org
Introduction Aging plays a major role in neurodegenerative disorders such as Alzheimer's
disease, and impacts neuronal loss. Olfactory dysfunction can be an early alteration …