Active fluids exhibit spontaneous flows with complex spatiotemporal structure, which have
been observed in bacterial suspensions, sperm cells, cytoskeletal suspensions, self …

Collective cell migration is a key driver of embryonic development, wound healing, and
some types of cancer invasion. Here, we provide a physical perspective of the mechanisms …

Abstract Development, regeneration and cancer involve drastic transitions in tissue
morphology. In analogy with the behaviour of inert fluids, some of these transitions have …

We investigate the large length and long time scales collective flows and structural
rearrangements within in vitro human bronchial epithelial cell (HBEC) cultures. Activity …

We review recent evidence showing that cell and tissue dynamics are governed by
mesoscale physical principles. These principles can be understood in terms of simple state …

A striking phenomenon of collective cell motion is that they can exhibit a spontaneously
emerging wave during epithelia expansions. However, the fundamental mechanism …

The directed migration of cellular clusters enables morphogenesis, wound healing and
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …

In collective cell migration, the motion results from forces produced by each cell and
transmitted to the neighboring cells and to the substrate. Because inertia is negligible and …

During development, wound healing and cancer invasion, migrating cell clusters feature
highly protrusive leader cells at their front. Leader cells are thought to pull and direct their …

Spatiotemporal patterns in multicellular systems are important to understanding tissue
dynamics, for instance, during embryonic development and disease. Here, we use a …