Notch signaling defines an evolutionarily ancient cell interaction mechanism, which plays a
fundamental role in metazoan development. Signals exchanged between neighboring cells …

The Wnt and Notch signalling pathways represent two major channels of communication
used by animal cells to control their identities and behaviour during development. A number …

A fundamental goal of genetics and functional genomics is to identify and mutate every gene
in model organisms such as Drosophila melanogaster. The Berkeley Drosophila Genome …

Alagille syndrome is a human autosomal dominant developmental disorder characterized by
liver, heart, eye, skeletal, craniofacial and kidney abnormalities. Alagille syndrome is caused …

AB lymphocyte hyperactivity syndrome resembling systemic lupus erythematosus
characterizes mice lacking the src-family kinase Lyn. Lyn is not required to initiate B cell …

The core promoter is the ultimate target of the vast network of regulatory factors that
contribute to the initiation of transcription by RNA polymerase II. Here we describe the MTE …

Notch plays an important role in cell fate decisions in uncommitted proliferative cells,
including neurogenesis, but is believed to not have a role in postmitotic cells. We have …

The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central
components in the Notch pathway, a fundamental cell signaling system that regulates …

The Drosophila eye is a highly ordered epithelial tissue composed of∼ 750 subunits called
ommatidia arranged in a reiterated hexagonal pattern. At higher resolution, observation of …

This FlyBook chapter summarizes the history and the current state of our understanding of
the Wingless signaling pathway. Wingless, the fly homolog of the mammalian Wnt …