Biosensors integrated 3D organoid/organ-on-a-chip system: A real-time biomechanical, biophysical, and biochemical monitoring and characterization

S Liu, S Kumari, H He, P Mishra, BN Singh… - Biosensors and …, 2023 - Elsevier
As a full-fidelity simulation of human cells, tissues, organs, and even systems at the
microscopic scale, Organ-on-a-Chip (OOC) has significant ethical advantages and …

Engineering brain-on-a-chip platforms

B Servais, N Mahmoudi, V Gautam, W Tong… - Nature Reviews …, 2024 - nature.com
The increasing prevalence of neurological and psychiatric diseases, such as Alzheimer
disease and schizophrenia, necessitates the development of new research tools to …

Advancing nerve regeneration: Peripheral nerve injury (PNI) chip empowering high-speed biomaterial and drug screening

D Lee, HQ Tran, AT Dudley, K Yang, Z Yan… - Chemical Engineering …, 2024 - Elsevier
Peripheral nerve injuries (PNIs) represent a significant challenge in regenerative medicine,
often leading to long-term functional impairments. In this study, we introduce the peripheral …

Brain organoids are new tool for drug screening of neurological diseases

JQ Zhou, LH Zeng, CT Li, DH He… - Neural Regeneration …, 2023 - journals.lww.com
At the level of in vitro drug screening, the development of a phenotypic analysis system with
high-content screening at the core provides a strong platform to support high-throughput …

Biosensor integrated brain-on-a-chip platforms: progress and prospects in clinical translation

B Cecen, E Saygili, I Zare, O Nejati, D Khorsandi… - Biosensors and …, 2023 - Elsevier
Because of the brain's complexity, develo** effective treatments for neurological disorders
is a formidable challenge. Research efforts to this end are advancing as in vitro systems …

[HTML][HTML] Advances of 3D Cell Co-Culture Technology Based on Microfluidic Chips

C Li, W He, Y Song, X Zhang, J Sun, Z Zhou - Biosensors, 2024 - mdpi.com
Cell co-culture technology aims to study the communication mechanism between cells and
to better reveal the interactions and regulatory mechanisms involved in processes such as …

Tailoring Physicochemical Properties of Photothermal Hydrogels Toward Intrinsically Regenerative Therapies

T **ao, H Dai, Y Wu, Z Liu, J Yeow… - Advanced Functional …, 2025 - Wiley Online Library
Photothermal hydrogels (PTHs) are considered next‐generation biomaterials as they offer
remotely defined biophysical information of the extracellular milieu. PTHs allow precise and …

Brain organoid-on-a-chip: A next-generation human brain avatar for recapitulating human brain physiology and pathology

J Song, S Bang, N Choi, HN Kim - Biomicrofluidics, 2022 - pubs.aip.org
Neurodegenerative diseases and neurodevelopmental disorders have become increasingly
prevalent; however, the development of new pharmaceuticals to treat these diseases has …

Overview on microfluidics devices for monitoring brain disorder biomarkers

C Nix, M Ghassemi, J Crommen, M Fillet - TrAC Trends in Analytical …, 2022 - Elsevier
Neurological disorders are one of the leading causes of disability and death worldwide. The
complexity of the human brain and therefore the significant structural gap between animal …

Brain-on-a-chip: an emerging platform for studying the nanotechnology-biology interface for neurodegenerative disorders

RO Rodrigues, SR Shin, M Bañobre-López - Journal of …, 2024 - Springer
Neurological disorders have for a long time been a global challenge dismissed by drug
companies, especially due to the low efficiency of most therapeutic compounds to cross the …