Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression
Prostate cancer shows remarkable clinical heterogeneity, which manifests in spatial and
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
clonal genomic diversity. By contrast, the transcriptomic heterogeneity of prostate tumours is …
Molecular landmarks of tumor hypoxia across cancer types
Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …
[HTML][HTML] Widespread and functional RNA circularization in localized prostate cancer
The cancer transcriptome is remarkably complex, including low-abundance transcripts,
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
many not polyadenylated. To fully characterize the transcriptome of localized prostate …
Visualization of very large high-dimensional data sets as minimum spanning trees
The chemical sciences are producing an unprecedented amount of large, high-dimensional
data sets containing chemical structures and associated properties. However, there are …
data sets containing chemical structures and associated properties. However, there are …
The proteogenomic landscape of curable prostate cancer
DNA sequencing has identified recurrent mutations that drive the aggressiveness of prostate
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
cancers. Surprisingly, the influence of genomic, epigenomic, and transcriptomic …
[HTML][HTML] A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling
Summary N 6-methyladenosine (m 6 A) of mRNAs modulated by the METTL3-METTL14-
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …
WTAP-RBM15 methyltransferase complex and m 6 A demethylases such as FTO play …
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and
treatment resistance. While epigenetic changes are well known to drive prostate lineage …
treatment resistance. While epigenetic changes are well known to drive prostate lineage …
Sex differences in cancer driver genes and biomarkers
Cancer differs significantly between men and women; even after adjusting for known
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
epidemiologic risk factors, the sexes differ in incidence, outcome, and response to therapy …
Drug screening at single-organoid resolution via bioprinting and interferometry
High throughput drug screening is an established approach to investigate tumor biology and
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …
identify therapeutic leads. Traditional platforms use two-dimensional cultures which do not …
Divergent mutational processes distinguish hypoxic and normoxic tumours
Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours
respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly …
respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly …