The future of rodent models in depression research
Currently, over 300 million people worldwide have depression, and the socioeconomic
burden of this debilitating disorder is anticipated to increase markedly over the coming …
burden of this debilitating disorder is anticipated to increase markedly over the coming …
Precision epidemiology for infectious disease control
Advances in genomics and computing are transforming the capacity for the characterization
of biological systems, and researchers are now poised for a precision-focused …
of biological systems, and researchers are now poised for a precision-focused …
Mouse genome database (MGD) 2019
Abstract The Mouse Genome Database (MGD; http://www. informatics. jax. org) is the
community model organism genetic and genome resource for the laboratory mouse. MGD is …
community model organism genetic and genome resource for the laboratory mouse. MGD is …
Bringing the animal QTLdb and CorrDB into the future: meeting new challenges and providing updated services
Abstract The Animal QTLdb (https://www. animalgenome. org/QTLdb) and CorrDB
(https://www. animalgenome. org/CorrDB) are unique resources for livestock animal …
(https://www. animalgenome. org/CorrDB) are unique resources for livestock animal …
A genetic mouse model recapitulates immune checkpoint inhibitor–associated myocarditis and supports a mechanism-based therapeutic intervention
Immune checkpoint inhibitors (ICI) targeting CTLA4 or PD-1/PD-L1 have transformed cancer
therapy but are associated with immune-related adverse events, including myocarditis …
therapy but are associated with immune-related adverse events, including myocarditis …
The Monarch Initiative in 2019: an integrative data and analytic platform connecting phenotypes to genotypes across species
In biology and biomedicine, relating phenotypic outcomes with genetic variation and
environmental factors remains a challenge: patient phenotypes may not match known …
environmental factors remains a challenge: patient phenotypes may not match known …
[HTML][HTML] Gene-by-environment interactions in Alzheimer's disease and Parkinson's disease
Diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD) arise from
complex interactions of genetic and environmental factors, with genetic variants regulating …
complex interactions of genetic and environmental factors, with genetic variants regulating …
Analysis of genetically diverse macrophages reveals local and domain-wide mechanisms that control transcription factor binding and function
Non-coding genetic variation is a major driver of phenotypic diversity and allows the
investigation of mechanisms that control gene expression. Here, we systematically …
investigation of mechanisms that control gene expression. Here, we systematically …
Robust mouse tracking in complex environments using neural networks
The ability to track animals accurately is critical for behavioral experiments. For video-based
assays, this is often accomplished by manipulating environmental conditions to increase …
assays, this is often accomplished by manipulating environmental conditions to increase …
Chemical-induced phenotypes at CTD help inform the predisease state and construct adverse outcome pathways
AP Davis, TC Wiegers, J Wiegers… - Toxicological …, 2018 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org) is a public
resource that manually curates the scientific literature to provide content that illuminates the …
resource that manually curates the scientific literature to provide content that illuminates the …