[HTML][HTML] 13 reasons why the brain is susceptible to oxidative stress
The human brain consumes 20% of the total basal oxygen (O 2) budget to support ATP
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
intensive neuronal activity. Without sufficient O 2 to support ATP demands, neuronal activity …
A comprehensive review of monoamine oxidase inhibitors as Anti-Alzheimer's disease agents: A review
Monoamine oxidases (MAO-A and MAO-B) are mammalian flavoenzyme, which catalyze the
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
oxidative deamination of several neurotransmitters like norepinephrine, dopamine, tyramine …
Small-molecule probes from bench to bedside: advancing molecular analysis of drug–target interactions toward precision medicine
Over the past decade, remarkable advances have been witnessed in the development of
small-molecule probes. These molecular tools have been widely applied for interrogating …
small-molecule probes. These molecular tools have been widely applied for interrogating …
Comprehensive review of mechanisms of pathogenesis involved in Alzheimer's disease and potential therapeutic strategies
AD is a progressive neurodegenerative disorder and a leading cause of dementia in an
aging population worldwide. The enormous challenge which AD possesses to global …
aging population worldwide. The enormous challenge which AD possesses to global …
Mitochondrial ROS formation in the pathogenesis of diabetic cardiomyopathy
N Kaludercic, F Di Lisa - Frontiers in Cardiovascular Medicine, 2020 - frontiersin.org
Diabetic cardiomyopathy is a result of diabetes-induced changes in the structure and
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …
function of the heart. Hyperglycemia affects multiple pathways in the diabetic heart, but …
Inhibitors of MAO-A and MAO-B in psychiatry and neurology
JPM Finberg, JM Rabey - Frontiers in pharmacology, 2016 - frontiersin.org
Inhibitors of MAO-A and MAO-B are in clinical use for the treatment of psychiatric and
neurological disorders respectively. Elucidation of the molecular structure of the active sites …
neurological disorders respectively. Elucidation of the molecular structure of the active sites …
[LIVRE][B] Janeway immunologie
Jetzt wieder auf dem neuesten Stand: DIE Einführung in die Immunologie für Studierende
der Biowissenschaften und der Medizin Der Janeway, das bewährte und viel gelobte …
der Biowissenschaften und der Medizin Der Janeway, das bewährte und viel gelobte …
Assessment of enzyme inhibition: a review with examples from the development of monoamine oxidase and cholinesterase inhibitory drugs
RR Ramsay, KF Tipton - Molecules, 2017 - mdpi.com
The actions of many drugs involve enzyme inhibition. This is exemplified by the inhibitors of
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
monoamine oxidases (MAO) and the cholinsterases (ChE) that have been used for several …
The therapeutic potential of monoamine oxidase inhibitors
MBH Youdim, D Edmondson, KF Tipton - Nature reviews neuroscience, 2006 - nature.com
Monoamine oxidase inhibitors were among the first antidepressants to be discovered and
have long been used as such. It now seems that many of these agents might have …
have long been used as such. It now seems that many of these agents might have …
On the clinical pharmacology of reactive oxygen species
Reactive oxygen species (ROS) have been correlated with almost every human disease. Yet
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …
clinical exploitation of these hypotheses by pharmacological modulation of ROS has been …