The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

The size and surface area of the mammalian brain are thought to be critical determinants of
intellectual ability. Recent studies show that development of the gyrated human neocortex …

The origin of life is a fascinating, unresolved problem whose deciphering would have
important scientific, epistemological and social implications. Over time, philosophers and …

Notch proteins are cell surface receptors that mediate developmental cell specification
events. To explore the function of murine Notch1, an essential portion of the gene was …

Circadian rhythms are daily cycles of physiology and behaviour that are driven by an
endogenous oscillator with a period of approximately (circa-) one day (diem). Exemplified in …

The Notch signalling pathway mediates cell fate decisions, and is tumour suppressive or
oncogenic depending on the context,. During lung development, Notch pathway activation …

Qu'est-ce que le passé, sinon du présent qui est en retard? Pierre Dac (l'osa moelle, March
1940) Modeling automatic engines or physiological systems often involves the idea of …

The Notch signaling pathway comprises multiple ligands that are used in distinct biological
contexts. In principle, different ligands could activate distinct target programs in signal …

Visualization of the transcriptome and the nuclear organization in situ has been challenging
for single-cell analysis. Here, we demonstrate a multiplexed single-molecule in situ method …

The mammalian circadian timing system is composed of almost as many individual clocks as
there are cells. These countless oscillators have to be synchronized by a central pacemaker …