Advances in organ-on-a-chip engineering
Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
and discovery processes. The cost of drug discovery is steadily increasing owing to the …
Development of polymeric nanoparticles for blood–brain barrier transfer—strategies and challenges
Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …
Spheroids as a type of three-dimensional cell cultures—examples of methods of preparation and the most important application
K Białkowska, P Komorowski, M Bryszewska… - International journal of …, 2020 - mdpi.com
Cell cultures are very important for testing materials and drugs, and in the examination of
cell biology and special cell mechanisms. The most popular models of cell culture are two …
cell biology and special cell mechanisms. The most popular models of cell culture are two …
Multiorgan-on-a-chip: a systemic approach to model and decipher inter-organ communication
N Picollet-D'hahan, A Zuchowska, I Lemeunier… - Trends in …, 2021 - cell.com
Multiorgan-on-a-chip (multi-OoC) platforms have great potential to redefine the way in which
human health research is conducted. After briefly reviewing the need for comprehensive …
human health research is conducted. After briefly reviewing the need for comprehensive …
In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
[HTML][HTML] Microfluidic 3D cell culture: from tools to tissue models
Highlights•Comprehensive review of advances in microfluidic 3D cell culture since
2012.•Increased physiological relevance by precise control of cellular microenvironment.• …
2012.•Increased physiological relevance by precise control of cellular microenvironment.• …
Organ-on-a-chip devices advance to market
To curb the high cost of drug development, there is an urgent need to develop more
predictive tissue models using human cells to determine drug efficacy and safety in advance …
predictive tissue models using human cells to determine drug efficacy and safety in advance …
[HTML][HTML] Derivation of human midbrain-specific organoids from neuroepithelial stem cells
Research on human brain development and neurological diseases is limited by the lack of
advanced experimental in vitro models that truly recapitulate the complexity of the human …
advanced experimental in vitro models that truly recapitulate the complexity of the human …
High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
Parkinson's disease and related synucleinopathies are characterized by the abnormal
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of …
accumulation of alpha-synuclein aggregates, loss of dopaminergic neurons, and gliosis of …