Hepatocyte transplantation has shown potential as an additional treatment modality for
certain diseases of the liver. To date, patients with liver-based metabolic disorders or acute …

On September 6 and 7, 2009 a meeting was held in London to identify and discuss what are
perceived to be current roadblocks to effective hepatocyte transplantation as it is currently …

Objective: The hepatic integration of human adipose tissue derived mesenchymal stem cells
(hAT-MSCs) in vivo with or without prior differentiation to hepatocyte-like cells in vitro was …

Since the first human hepatocyte transplants (HTx) in 1992, clinical studies have clearly
established proof of principle for this therapy as a treatment for patients with acquired or …

Transplantation of healthy cells to repair organ damage or replace deficient functions
constitutes a major goal of cell therapy. However, the mechanisms by which transplanted …

The prevalence of liver diseases is increasing globally. Orthotopic liver transplantation is
widely used to treat liver disease upon organ failure. The complexity of this procedure and …

Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by
the destruction of fenestrae and appears under pathological conditions; nevertheless, their …

Liver cell transplantation is an attractive technique to treat liver-based inborn errors of
metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to …

Stem cells from extra-or intrahepatic sources have been recently characterized and their
usefulness for the generation of hepatocyte-like lineages has been demonstrated …

More than 30 years after the first hepatocyte transplant to treat the Gunn rat, the animal
model for Crigler‐Najjar syndrome, there are still a number of impediments to hepatocyte …