Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

Physical stimuli are essential for the function of eukaryotic cells, and changes in physical
signals are important elements in normal tissue development as well as in disease initiation …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

YAP/TAZ is a master regulator of mechanotransduction whose functions rely on
translocation from the cytoplasm to the nucleus in response to diverse physical cues …

Blood and lymphatic vessels are lined by endothelial cells which constantly interact with
their luminal and abluminal extracellular environments. These interactions confer physical …

Heterogeneous subtypes of cancer-associated fibroblasts (CAFs) coexist within pancreatic
cancer tissues and can both promote and restrain disease progression. Here, we interrogate …

Abstract The Rho GTPases RhoA, Rac1, and Cdc42 are important regulators of cytoskeletal
dynamics. Although many in vitro and in vivo data indicate tumor-promoting effects of …

Filamentous actin (F-actin) provides cells with mechanical support and promotes the mobility
of intracellular structures. Although F-actin is traditionally considered to be cytoplasmic, here …

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between
tumor cells and the stroma to promote tumor progression. Consequently, strategies to target …