Specific miRNA disease biomarkers in blood, serum and plasma: challenges and prospects

C Backes, E Meese, A Keller - Molecular diagnosis & therapy, 2016 - Springer
Significant effort has been devoted to discovering microRNA (miRNA) disease biomarkers.
In particular, miRNAs in whole blood or specific blood components are candidates for …

The translational potential of microRNAs as biofluid markers of urological tumours

A Fendler, C Stephan, GM Yousef… - Nature Reviews …, 2016 - nature.com
MicroRNAs (miRNAs) are secreted by cells in vesicles, bound in a ribonucleoprotein
complex or as free molecules. These miRNA secretion pathways are dysregulated in cancer …

Exosomal and non‐exosomal urinary miRNAs in prostate cancer detection and prognosis

L Foj, F Ferrer, M Serra, A Arévalo, M Gavagnach… - The …, 2017 - Wiley Online Library
BACKGROUND MicroRNAs (miRNAs) are non‐coding small RNAs, involved in post‐
transcriptional regulation of many target genes. METHODS Five miRNAs that have been …

Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer

S Shin, YH Park, SH Jung, SH Jang, MY Kim… - NPJ Genomic …, 2021 - nature.com
Predicting the risk of metastasis before starting prostate cancer (PCa) treatment can
minimize the overtreatment of indolent cases and help choosing appropriate treatment. The …

Non-invasive prostate cancer detection by measuring miRNA variants (isomiRs) in urine extracellular vesicles

D Koppers-Lalic, M Hackenberg, R De Menezes… - …, 2016 - pmc.ncbi.nlm.nih.gov
In many cancer types, the expression and function of∼ 22 nucleotide-long microRNAs
(miRNA) is deregulated. Mature miRNAs can be stably detected in extracellular vesicles …

Detection of inflammatory biomarkers in saliva and urine: potential in diagnosis, prevention, and treatment for chronic diseases

S Prasad, AK Tyagi… - Experimental Biology and …, 2016 - journals.sagepub.com
Inflammation is a part of the complex biological response of inflammatory cells to harmful
stimuli, such as pathogens, irritants, or damaged cells. This inflammation has been linked to …

miRNAs as novel biomarkers in the management of prostate cancer

X Filella, L Foj - Clinical Chemistry and Laboratory Medicine (CCLM), 2017 - degruyter.com
Abstract microRNAs (miRNAs) are small non-coding RNAs that control gene expression
posttranscriptionally and are part of the giant non codifying genoma. Cumulating data …

Prognostic value of miR-21 for prostate cancer: a systematic review and meta-analysis

MYC Stafford, CE Willoughby, CP Walsh… - Bioscience …, 2022 - portlandpress.com
Elevated levels of miR-21 expression are associated with many cancers, suggesting it may
be a promising clinical biomarker. In prostate cancer (PCa), however, there is still no …

Exosomal microRNAs in cancer: Potential biomarkers and immunotherapeutic targets for immune checkpoint molecules

F Alotaibi - Frontiers in Genetics, 2023 - frontiersin.org
Exosomes are small extracellular vesicles with a lipid bilayer structure secreted from
different cell types which can be found in various body fluids including blood, pleural fluid …

Noncoding RNAs as novel biomarkers in prostate cancer

CGH Rönnau, GW Verhaegh… - BioMed research …, 2014 - Wiley Online Library
Prostate cancer (PCa) is the second most common diagnosed malignant disease in men
worldwide. Although serum PSA test dramatically improved the early diagnosis of PCa, it …