Comparative oncology is poised to have a far-reaching impact on both animals and human
beings with cancer. The field is gaining momentum and has repeatedly proven its utility in …

Failure of analgesic drugs in clinical development is common. Along with the current
“reproducibility crisis” in pain research, this has led some to question the use of animal …

Abstract Background The international Dog10K project aims to sequence and analyze
several thousand canine genomes. Incorporating 20× data from 1987 individuals, including …

Launched in 2001 to showcase the draft human genome assembly, the UCSC Genome
Browser database (http://genome. ucsc. edu) and associated tools continue to grow …

Whole transcriptome sequencing (RNA-seq) has become a standard for cataloguing and
monitoring RNA populations. One of the main bottlenecks, however, is to correctly identify …

Abstract The recent pandemic, COVID-19, is caused by a novel coronavirus, SARS-CoV-2,
with elusive origin. SARS-CoV-2 infects mammalian cells via ACE2, a transmembrane …

Selective breeding of domestic dogs has generated diverse breeds often optimized for
performing specialized tasks. Despite the heritability of breed-typical behavioral traits …

Chondrodystrophy in dogs is defined by dysplastic, shortened long bones and premature
degeneration and calcification of intervertebral discs. Independent genome-wide …

Purpose Given the unmet need for novel immunotherapy in soft tissue sarcoma (STS), we
sought to characterize the phenotype and function of intratumoral natural killer (NK) and T …

Duchenne muscular dystrophy (DMD), caused by mutations at the dystrophin gene, is the
most common form of muscular dystrophy. There is no cure for DMD and current therapeutic …