The interaction between NF-κB and estrogen in Alzheimer's disease

P Mishra, DA Davies, BC Albensi - Molecular neurobiology, 2023 - Springer
Post-menopausal women are at a higher risk of develo** Alzheimer's disease (AD) than
males. The higher rates of AD in women are associated with the sharp decline in the …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway

S Dai, J Wei, H Zhang, P Luo, Y Yang, X Jiang… - Journal of …, 2022 - Springer
Background Inflammation contributes to the poor prognosis of intracerebral hemorrhage
(ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in …

Menopause-associated depression: impact of oxidative stress and neuroinflammation on the central nervous system—a review

G Liang, ASF Kow, R Yusof, CL Tham, YC Ho, MT Lee - Biomedicines, 2024 - mdpi.com
Perimenopausal depression, occurring shortly before or after menopause, is characterized
by symptoms such as emotional depression, anxiety, and stress, often accompanied by …

[HTML][HTML] Sex hormones, neurosteroids, and glutamatergic neurotransmission: A review of the literature

MJ Goyette, SL Murray, CJ Saldanha, K Holton - Neuroendocrinology, 2023 - karger.com
Glutamatergic dysfunction has been implicated in the pathophysiology of multiple conditions
including epilepsy, chronic pain, post-traumatic stress disorder (PTSD), and premenstrual …

17β-estradiol abrogates oxidative stress and neuroinflammation after cortical stab wound injury

K Saeed, MH Jo, JS Park, SI Alam, I Khan, R Ahmad… - Antioxidants, 2021 - mdpi.com
Disruptions in brain energy metabolism, oxidative damage, and neuroinflammation are
commonly seen in traumatic brain injury (TBI). Microglial activation is the hallmark of …

Estrogen signalling and Alzheimer's disease: Decoding molecular mechanisms for therapeutic breakthrough

Rishabh, M Rohilla, S Bansal, N Bansal… - European Journal of …, 2024 - Wiley Online Library
In females, Alzheimer's disease (AD) incidences increases as compared to males due to
estrogen deficiency after menopause. Estrogen therapy is the mainstay therapy for …

[HTML][HTML] Intermittent fasting alleviates type 1 diabetes-induced cognitive dysfunction by improving the frontal cortical metabolic disorder

F **ong, K Jiang, Y Wu, C Lou, C Ding, W Zhang… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Intermittent fasting (IF) is an ecological strategy to control various metabolic disorder
symptoms, but its protective effect on type 1 diabetes (T1D)-induced cognitive dysfunction …

[HTML][HTML] Aspalathus linearis (Rooibos) and Agmatine May Act Synergistically to Beneficially Modulate Intestinal Tight Junction Integrity and Inflammatory Profile

L Pretorius, C Smith - Pharmaceuticals, 2022 - mdpi.com
In order to promote gastrointestinal health, significant increases in the prevalence of
gastrointestinal disorders should be paralleled by similar surges in therapeutics research …

Anticonvulsant effect of glycitin in pentylenetetrazol induced male Wistar rat model by targeting oxidative stress and Nrf2/HO-1 signaling

S Hakimi Naeini, H Rajabi-Maham, V Azizi… - Frontiers in …, 2024 - frontiersin.org
Epilepsy, characterized by recurrent seizures, poses a significant health challenge globally.
Despite the availability of anti-seizure medications, their adverse effects and inadequate …