Coiled‐coils: The long and short of it
L Truebestein, TA Leonard - Bioessays, 2016 - Wiley Online Library
Coiled‐coils are found in proteins throughout all three kingdoms of life. Coiled‐coil domains
of some proteins are almost invariant in sequence and length, betraying a structural and …
of some proteins are almost invariant in sequence and length, betraying a structural and …
[HTML][HTML] The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance
PP Ruvolo - BBA clinical, 2016 - Elsevier
Aberrant activation of signal transduction pathways can transform a normal cell to a
malignant one and can impart survival properties that render cancer cells resistant to …
malignant one and can impart survival properties that render cancer cells resistant to …
Protein phosphatase 2A–structure, function and role in neurodevelopmental disorders
Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …
STRIPAK, a highly conserved signaling complex, controls multiple eukaryotic cellular and developmental processes and is linked with human diseases
U Kück, D Radchenko, I Teichert - Biological chemistry, 2019 - degruyter.com
The striatin-interacting phosphatases and kinases (STRIPAK) complex is evolutionary highly
conserved and has been structurally and functionally described in diverse lower and higher …
conserved and has been structurally and functionally described in diverse lower and higher …
Cryo-EM structure of the Hippo signaling integrator human STRIPAK
The striatin-interacting phosphatase and kinase (STRIPAK) complex is a large, multisubunit
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …
protein phosphatase 2A (PP2A) assembly that integrates diverse cellular signals in the …
Recurrent PPP2R1A Mutations in Uterine Cancer Act through a Dominant-Negative Mechanism to Promote Malignant Cell Growth
D Haesen, L Abbasi Asbagh, R Derua, A Hubert… - Cancer research, 2016 - AACR
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold
subunit gene PPP2R1A are among the few genomic alterations that occur frequently in …
subunit gene PPP2R1A are among the few genomic alterations that occur frequently in …
A STRIPAK complex mediates axonal transport of autophagosomes and dense core vesicles through PP2A regulation
AL Neisch, TP Neufeld, TS Hays - Journal of Cell Biology, 2017 - rupress.org
Autophagy plays an essential role in the cellular homeostasis of neurons, facilitating the
clearance of cellular debris. This clearance process is orchestrated through the assembly …
clearance of cellular debris. This clearance process is orchestrated through the assembly …
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
Alterations involving serine-threonine phosphatase PP2A subunits occur in a range of
human cancers, and partial loss of PP2A function contributes to cell transformation …
human cancers, and partial loss of PP2A function contributes to cell transformation …
PP2A holoenzymes, substrate specificity driving cellular functions and deregulation in cancer
PP2A is a highly conserved eukaryotic serine/threonine protein phosphatase of the PPP
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …
family of phosphatases with fundamental cellular functions. In cells, PP2A targets specific …
The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction
L Lenaerts, S Reynhout, I Verbinnen… - Genetics in …, 2021 - nature.com
Purpose Neurodevelopmental disorders (NDD) caused by protein phosphatase 2A (PP2A)
dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA …
dysfunction have mainly been associated with de novo variants in PPP2R5D and PPP2CA …