The lamprey belongs to the phylogenetically oldest group of vertebrates that diverged from
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …

Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …

The brain is composed of complex networks of interacting neurons that express
considerable heterogeneity in their physiology and spiking characteristics. How does this …

Rhythmic gene expression is found throughout the central nervous system. This harmonized
regulation can be dependent on-and independent of-the master regulator of biological …

The cortico–basal ganglia–thalamo–cortical loop is one of the fundamental network motifs in
the brain. Revealing its structural and functional organization is critical to understanding …

Striosomes form neurochemically specialized compartments of the striatum embedded in a
large matrix made up of modules called matrisomes. Striosome-matrix architecture is …

In mammalian animal models, high-resolution kinematic tracking is restricted to brief
sessions in constrained environments, limiting our ability to probe naturalistic behaviors and …

Dysfunctions in frontostriatal brain circuits have been implicated in neuropsychiatric
disorders, including those characterized by the presence of repetitive behaviors. We …

In physiological conditions, adult neurons have low intracellular Cl−[(Cl−) I] levels
underlying the γ-aminobutyric acid (GABA) ergic inhibitory drive. In contrast, neurons have …

The striatum has been involved in complex behaviors such as motor control, learning,
decision-making, reward and aversion. The striatum is mainly composed of medium spiny …